Potentiometric detection of thiols: a mechanistic evaluation of quinone-thiol interactions

A Digga, S Gracheva, C Livingstone, J Davis

    Research output: Contribution to journalArticle

    26 Citations (Scopus)

    Abstract

    The potentiometric response resulting from the sequential addition of reduced thiols to a benzoquinone/hydroquinone couple has been investigated. The system has been shown to offer a simple route through which thiol could be quantified but a discrepancy in the reaction stoichiometry between glutathione and cysteine was observed. A mechanistic appraisal of the quinone-thiol interactions has been conducted and the proposed reaction pathways corroborated by spectroscopic analysis. (C) 2003 Published by Elsevier B.V.
    LanguageEnglish
    Pages732-736
    JournalElectrochemistry Communications
    Volume5
    Issue number8
    DOIs
    Publication statusPublished - Aug 2003

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    Sulfhydryl Compounds
    Spectroscopic analysis
    Stoichiometry
    Glutathione
    Cysteine
    benzoquinone

    Cite this

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    Potentiometric detection of thiols: a mechanistic evaluation of quinone-thiol interactions. / Digga, A; Gracheva, S; Livingstone, C; Davis, J.

    In: Electrochemistry Communications, Vol. 5, No. 8, 08.2003, p. 732-736.

    Research output: Contribution to journalArticle

    TY - JOUR

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    AU - Gracheva, S

    AU - Livingstone, C

    AU - Davis, J

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    AB - The potentiometric response resulting from the sequential addition of reduced thiols to a benzoquinone/hydroquinone couple has been investigated. The system has been shown to offer a simple route through which thiol could be quantified but a discrepancy in the reaction stoichiometry between glutathione and cysteine was observed. A mechanistic appraisal of the quinone-thiol interactions has been conducted and the proposed reaction pathways corroborated by spectroscopic analysis. (C) 2003 Published by Elsevier B.V.

    U2 - 10.1016/S1388-2481(03)00172-3

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    JO - Electrochemistry Communications

    T2 - Electrochemistry Communications

    JF - Electrochemistry Communications

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