The potentiometric response resulting from the sequential addition of reduced thiols to a benzoquinone/hydroquinone couple has been investigated. The system has been shown to offer a simple route through which thiol could be quantified but a discrepancy in the reaction stoichiometry between glutathione and cysteine was observed. A mechanistic appraisal of the quinone-thiol interactions has been conducted and the proposed reaction pathways corroborated by spectroscopic analysis. (C) 2003 Published by Elsevier B.V.
Digga, A., Gracheva, S., Livingstone, C., & Davis, J. (2003). Potentiometric detection of thiols: a mechanistic evaluation of quinone-thiol interactions. Electrochemistry Communications, 5(8), 732-736. https://doi.org/10.1016/S1388-2481(03)00172-3