Potential Modulation of Vascular Function Relating to Baseline Hydration Status in Healthy Human Participants in a Randomised Controlled Trial

Marietta Sayegh, Sumantra Ray

    Research output: Contribution to journalArticle

    Abstract

    Endothelium plays a pivotal role in vascular homeostasis. Vascular and endothelial function can be measured objectively in human volunteers using macro and micro vascular measures and other classical cardiovascular risk markers. Evidence is scarce regarding the possible effect that water (hydration) or its lack (dehydration) may have on relatively well validated surrogate measures of vascular structure and function. This study aimed to quantify the associations between hydration status measured using several hydration markers on key vascular function markers in males and females. Forty overweight and obese but otherwise healthy participants were recruited for this analysis between July 2013 and June 2014. Participants were fasted for 12 hours prior to their visit. Participants attended the MRC Human Nutrition Research unit for a baseline visit where hydration status was estimated both on the day and using 24 hour urine volume. Vascular function was also measured on the day. Univariate and multivariate regression analyses revealed that 24 hour urine volume was statistically associated with augmentation index (AIx) calculated using PWA in women (P<0.05). Similarly, volume of water consumed per minute, USG and 24hrs urine osmolality were significantly associated with LDI in women (P<0.05). Age and urine osmolality were found to be statistically associated with LDI in men (P<0.01). No other significant differences were observed. These data suggest that future nutrition and vascular function research studies may have to adjust for hydration status especially where PWA and LDI are key measures in order to increase accuracy of results.
    Original languageEnglish
    Article number584.26
    JournalThe FASEB Journal
    Volume29
    Issue number1_supplement
    Publication statusPublished - 1 Apr 2015

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