Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features

Sk. Sarif Hassan; Shinjini Ghosh; Diksha Attrish; Pabitra Pal Choudhury; Alaa A. A. Aljabali; Bruce D. Uhal; Kenneth Lundstrom; Nima Rezaei; Vladimir N. Uversky; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-aziz; Ramesh Kandimalla; Murtaza M. Tambuwala; Gajendra Kumar Azad; Samendra P. Sherchan; Wagner Baetas-da-cruz; Kazuo Takayama; Ángel Serrano-aroca; Gaurav Chauhan; Giorgio Palu; Adam M. Brufsky

doi:10.3390/molecules25245906

Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features

Sk. Sarif Hassan
, Shinjini Ghosh
, Diksha Attrish
, Pabitra Pal Choudhury
, Alaa A. A. Aljabali
, Bruce D. Uhal
, Kenneth Lundstrom
, Nima Rezaei
, Vladimir N. Uversky
, Murat Seyran
, Damiano Pizzol
, Parise Adadi
, Antonio Soares
, Tarek Mohamed Abd El-aziz
, Ramesh Kandimalla
, Murtaza M. Tambuwala
, Gajendra Kumar Azad
, Samendra P. Sherchan
, Wagner Baetas-da-cruz
, Kazuo Takayama

Ángel Serrano-aroca, Gaurav Chauhan, Giorgio Palu, Adam M. Brufsky

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

140 Downloads (Pure)

Abstract

Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22–42, aa 79–84, and aa 330–393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.

Original language	English
Article number	5906
Number of pages	23
Journal	Molecules
Volume	25
Issue number	24
Early online date	13 Dec 2020
DOIs	https://doi.org/10.3390/molecules25245906
Publication status	Published online - 13 Dec 2020

Bibliographical note

Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ACE2
SARS-CoV-2
bioinformatics
transmission
viral spike receptor-binding domain

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10.3390/molecules25245906Licence: CC BY

molecules-25-05906Final published version, 3.82 MBLicence: CC BY

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Hassan, S. S., Ghosh, S., Attrish, D., Choudhury, P. P., Aljabali, A. A. A., Uhal, B. D., Lundstrom, K., Rezaei, N., Uversky, V. N., Seyran, M., Pizzol, D., Adadi, P., Soares, A., El-aziz, T. M. A., Kandimalla, R., Tambuwala, M. M., Azad, G. K., Sherchan, S. P., Baetas-da-cruz, W., ... Brufsky, A. M. (2020). Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features. Molecules, 25(24), Article 5906. Advance online publication. https://doi.org/10.3390/molecules25245906

@article{9ef78580ae8d486591be91328857f7a7,

title = "Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features",

abstract = "Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22–42, aa 79–84, and aa 330–393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.",

keywords = "ACE2, SARS-CoV-2, bioinformatics, transmission, viral spike receptor-binding domain",

author = "Hassan, \{Sk. Sarif\} and Shinjini Ghosh and Diksha Attrish and Choudhury, \{Pabitra Pal\} and Aljabali, \{Alaa A. A.\} and Uhal, \{Bruce D.\} and Kenneth Lundstrom and Nima Rezaei and Uversky, \{Vladimir N.\} and Murat Seyran and Damiano Pizzol and Parise Adadi and Antonio Soares and El-aziz, \{Tarek Mohamed Abd\} and Ramesh Kandimalla and Tambuwala, \{Murtaza M.\} and Azad, \{Gajendra Kumar\} and Sherchan, \{Samendra P.\} and Wagner Baetas-da-cruz and Kazuo Takayama and {\'A}ngel Serrano-aroca and Gaurav Chauhan and Giorgio Palu and Brufsky, \{Adam M.\}",

note = "Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine",

year = "2020",

month = dec,

day = "13",

doi = "10.3390/molecules25245906",

language = "English",

volume = "25",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute",

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}

Hassan, SS, Ghosh, S, Attrish, D, Choudhury, PP, Aljabali, AAA, Uhal, BD, Lundstrom, K, Rezaei, N, Uversky, VN, Seyran, M, Pizzol, D, Adadi, P, Soares, A, El-aziz, TMA, Kandimalla, R, Tambuwala, MM, Azad, GK, Sherchan, SP, Baetas-da-cruz, W, Takayama, K, Serrano-aroca, Á, Chauhan, G, Palu, G & Brufsky, AM 2020, 'Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features', Molecules, vol. 25, no. 24, 5906. https://doi.org/10.3390/molecules25245906

TY - JOUR

T1 - Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features

AU - Hassan, Sk. Sarif

AU - Ghosh, Shinjini

AU - Attrish, Diksha

AU - Choudhury, Pabitra Pal

AU - Aljabali, Alaa A. A.

AU - Uhal, Bruce D.

AU - Lundstrom, Kenneth

AU - Rezaei, Nima

AU - Uversky, Vladimir N.

AU - Seyran, Murat

AU - Pizzol, Damiano

AU - Adadi, Parise

AU - Soares, Antonio

AU - El-aziz, Tarek Mohamed Abd

AU - Kandimalla, Ramesh

AU - Tambuwala, Murtaza M.

AU - Azad, Gajendra Kumar

AU - Sherchan, Samendra P.

AU - Baetas-da-cruz, Wagner

AU - Takayama, Kazuo

AU - Serrano-aroca, Ángel

AU - Chauhan, Gaurav

AU - Palu, Giorgio

AU - Brufsky, Adam M.

N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

PY - 2020/12/13

Y1 - 2020/12/13

N2 - Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22–42, aa 79–84, and aa 330–393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.

AB - Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22–42, aa 79–84, and aa 330–393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.

KW - ACE2

KW - SARS-CoV-2

KW - bioinformatics

KW - transmission

KW - viral spike receptor-binding domain

UR - https://www.scopus.com/pages/publications/85098534015

U2 - 10.3390/molecules25245906

DO - 10.3390/molecules25245906

M3 - Article

C2 - 33322198

SN - 1420-3049

VL - 25

JO - Molecules

JF - Molecules

IS - 24

M1 - 5906

ER -

Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features

Abstract

Bibliographical note

UN SDGs

Keywords

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