Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features

Sk. Sarif Hassan, Shinjini Ghosh, Diksha Attrish, Pabitra Pal Choudhury, Alaa A. A. Aljabali, Bruce D. Uhal, Kenneth Lundstrom, Nima Rezaei, Vladimir N. Uversky, Murat Seyran, Damiano Pizzol, Parise Adadi, Antonio Soares, Tarek Mohamed Abd El-aziz, Ramesh Kandimalla, Murtaza M. Tambuwala, Gajendra Kumar Azad, Samendra P. Sherchan, Wagner Baetas-da-cruz, Kazuo TakayamaÁngel Serrano-aroca, Gaurav Chauhan, Giorgio Palu, Adam M. Brufsky

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Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22–42, aa 79–84, and aa 330–393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.
Original languageEnglish
Article number5906
Number of pages23
Issue number24
Early online date13 Dec 2020
Publication statusPublished online - 13 Dec 2020

Bibliographical note

This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine


  • ACE2
  • SARS-CoV-2
  • bioinformatics
  • transmission
  • viral spike receptor-binding domain


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