Positive interplay between FFAR4/GPR120, DPP-IV inhibition and GLP-1 in beta cell proliferation and glucose homeostasis in obese high fat fed mice

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Abstract

G-protein coupled receptor-120 (GPR120; FFAR4) is a free fatty acid receptor, widely researched for its glucoregulatory and insulin release activities. This study aimed to investigate the metabolic advantage of FFAR4/GPR120activation using combination therapy. C57BL/6 mice, fed a High Fat Diet (HFD) for 120 days to induce obesity-diabetes, were subsequently treated with a single daily oral dose of FFAR4/GPR120 agonist Compound A (CpdA) (0.1μmol/kg) alone or in combination with sitagliptin (50mg/kg) for 21 days. After 21-days, glucose homeostasis, islet morphology, plasma hormones and lipids, tissue genes (qPCR) and protein expression (immunocytochemistry) were assessed. Oral administration of CpdA improved glucose tolerance (34% p
Original languageEnglish
Article number171218
Pages (from-to)1-26
Number of pages26
JournalPeptides
Volume177
Early online date13 Apr 2024
DOIs
Publication statusPublished online - 13 Apr 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors

Data Access Statement

Data will be made available on request.

Keywords

  • Diabetes
  • Insulin
  • Incretin
  • GPR120
  • FFAR4
  • GLP-1

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