TY - JOUR
T1 - Porous yolk-shell particle engineering via nonsolvent-assisted trineedle coaxial electrospraying for burn-related wound healing
AU - Zhang, Chunchen
AU - Li, Yudong
AU - Hu, Yejun
AU - Peng, Yu
AU - Ahmad, Zeeshan
AU - Li, Jing Song
AU - Chang, Ming Wei
PY - 2019/2/27
Y1 - 2019/2/27
N2 - Yolk-shell particles (YSPs) have attracted increasing attention from various research fields because of their low density, large surface area, and excellent loading capacity. However, the fabrication of polymer-based porous YSPs remains a great challenge. In this work, multifunctional polycaprolactone YSPs were produced using trineedle coaxial electrospraying with a simple nonsolvent process. TiO 2 -Ag nanoparticles and Ganoderma lucidum polysaccharides (GLPs) were encapsulated into the outer shell of the YSPs as the major antibacterial and antioxidant components, whereas iron oxide (Fe 3 O 4 ) nanoparticles were incorporated into the inner core to act as a photothermal agent. The morphology and structure, chemical composition, biocompatibility, antioxidant, and antibacterial effects of the fabricated YSPs, photothermal effects, and the release profile of the encapsulated GLP were studied in vitro. Furthermore, the in vivo wound healing effects of the YSPs and the laser-assisted therapy were explored based on a burn wound model on c57 mice.
AB - Yolk-shell particles (YSPs) have attracted increasing attention from various research fields because of their low density, large surface area, and excellent loading capacity. However, the fabrication of polymer-based porous YSPs remains a great challenge. In this work, multifunctional polycaprolactone YSPs were produced using trineedle coaxial electrospraying with a simple nonsolvent process. TiO 2 -Ag nanoparticles and Ganoderma lucidum polysaccharides (GLPs) were encapsulated into the outer shell of the YSPs as the major antibacterial and antioxidant components, whereas iron oxide (Fe 3 O 4 ) nanoparticles were incorporated into the inner core to act as a photothermal agent. The morphology and structure, chemical composition, biocompatibility, antioxidant, and antibacterial effects of the fabricated YSPs, photothermal effects, and the release profile of the encapsulated GLP were studied in vitro. Furthermore, the in vivo wound healing effects of the YSPs and the laser-assisted therapy were explored based on a burn wound model on c57 mice.
KW - polymer-based particles
KW - porous yolk-shell microparticles
KW - nonsolvent method
KW - trineedle coaxial electrospraying
KW - burn wound healing
UR - http://www.scopus.com/inward/record.url?scp=85062328446&partnerID=8YFLogxK
UR - https://pure.ulster.ac.uk/en/publications/porous-yolk-shell-particle-engineering-via-nonsolvent-assisted-tr
U2 - 10.1021/acsami.8b22112
DO - 10.1021/acsami.8b22112
M3 - Article
C2 - 30730130
AN - SCOPUS:85062328446
SN - 1944-8244
VL - 11
SP - 7823
EP - 7835
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 8
ER -