Polyunsaturated fatty acid status and methylmercury exposure are not associated with leukocyte telomere length in mothers or their children in the Seychelles Child Development Study

Alison J. Yeates, Sally, W, Thurston, Huiqi Li, Maria S Mulhern, Emeir M McSorley, Gene, E. Watson, Conrad, F. Shamlaye, JJ Strain, Gary, J. Myers, Philip, W. Davidson, Edwin Van Wijngaarden, Karin Broberg

Research output: Contribution to journalArticle

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Abstract

ABSTRACTBackground Leukocyte telomere length (TL) is associated with age-related diseases and early mortality, but there is a lack of data on determinants of TL in early life. Evidence suggests that dietary intake of marine n-3 polyunsaturated fatty acids (PUFA) is protective of telomere attrition. Yet the effect of methylmercury (MeHg) exposure, also found in fish, on TL is unknown. Objective The aim of this study was to investigate associations between prenatal PUFA status, MeHg exposure and TL in mothers and children in the Seychelles, where fish consumption is high. Methods Blood samples collected from 229 mothers (at 28wk gestation and delivery) and children (at 5y of age) in the Seychelles Child Development Study Nutrition Cohort 1 were analyzed for PUFA concentrations. Prenatal Hg was measured in maternal hair collected at delivery. Postnatal Hg was also measured in children’s hair samples, using a cumulative metric derived from values obtained at 3-5y of age. Relative TL was measured in blood obtained from mothers at delivery, in cord blood, and in children at 5y of age by quantitative PCR. Linear regression models were used to investigate associations between PUFA status, MeHg exposure and TL.Results Neither prenatal PUFA status or MeHg exposure were associated with TL of the mother or child, nor with TL attrition rate. However a higher prenatal n-6/n-3 PUFA ratio was significantly associated with longer TL in the mothers (β= 0.001, P= 0.048). Child PUFA status and MeHg exposure were not associated with child TL. However greater values of family Hollingshead socioeconomic status (SES) at 9mo of age were significantly associated with longer TL in cord blood (β=0.005, P= 0.03). Conclusions We found no evidence that PUFA status or MeHg exposure are determinants of TL, in either the mother or child. However, our results support the hypothesis that family SES may be associated with child TL.
LanguageEnglish
Pages2018-2024
JournalJournal of Nutrition
Volume147
Issue number11
Early online date4 Oct 2017
DOIs
Publication statusPublished - 1 Nov 2017

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Seychelles
Telomere
Child Development
Unsaturated Fatty Acids
Leukocytes
Mothers
Omega-3 Fatty Acids
Fetal Blood
Social Class
Hair
Linear Models
Fishes

Keywords

  • Polyunsaturated fatty acid status
  • methylmercury exposure
  • telomere length
  • pregnancy
  • maternal infant nutrition
  • fish consumption
  • Seychelles Child Development Study

Cite this

Yeates, Alison J. ; Thurston, Sally, W, ; Li, Huiqi ; Mulhern, Maria S ; McSorley, Emeir M ; Watson, Gene, E. ; Shamlaye, Conrad, F. ; Strain, JJ ; Myers, Gary, J. ; Davidson, Philip, W. ; Van Wijngaarden, Edwin ; Broberg, Karin. / Polyunsaturated fatty acid status and methylmercury exposure are not associated with leukocyte telomere length in mothers or their children in the Seychelles Child Development Study. In: Journal of Nutrition. 2017 ; Vol. 147, No. 11. pp. 2018-2024.
@article{e8299398a2e149ffb59c140ce29178d4,
title = "Polyunsaturated fatty acid status and methylmercury exposure are not associated with leukocyte telomere length in mothers or their children in the Seychelles Child Development Study",
abstract = "ABSTRACTBackground Leukocyte telomere length (TL) is associated with age-related diseases and early mortality, but there is a lack of data on determinants of TL in early life. Evidence suggests that dietary intake of marine n-3 polyunsaturated fatty acids (PUFA) is protective of telomere attrition. Yet the effect of methylmercury (MeHg) exposure, also found in fish, on TL is unknown. Objective The aim of this study was to investigate associations between prenatal PUFA status, MeHg exposure and TL in mothers and children in the Seychelles, where fish consumption is high. Methods Blood samples collected from 229 mothers (at 28wk gestation and delivery) and children (at 5y of age) in the Seychelles Child Development Study Nutrition Cohort 1 were analyzed for PUFA concentrations. Prenatal Hg was measured in maternal hair collected at delivery. Postnatal Hg was also measured in children’s hair samples, using a cumulative metric derived from values obtained at 3-5y of age. Relative TL was measured in blood obtained from mothers at delivery, in cord blood, and in children at 5y of age by quantitative PCR. Linear regression models were used to investigate associations between PUFA status, MeHg exposure and TL.Results Neither prenatal PUFA status or MeHg exposure were associated with TL of the mother or child, nor with TL attrition rate. However a higher prenatal n-6/n-3 PUFA ratio was significantly associated with longer TL in the mothers (β= 0.001, P= 0.048). Child PUFA status and MeHg exposure were not associated with child TL. However greater values of family Hollingshead socioeconomic status (SES) at 9mo of age were significantly associated with longer TL in cord blood (β=0.005, P= 0.03). Conclusions We found no evidence that PUFA status or MeHg exposure are determinants of TL, in either the mother or child. However, our results support the hypothesis that family SES may be associated with child TL.",
keywords = "Polyunsaturated fatty acid status, methylmercury exposure, telomere length, pregnancy, maternal infant nutrition, fish consumption, Seychelles Child Development Study",
author = "Yeates, {Alison J.} and Thurston, {Sally, W,} and Huiqi Li and Mulhern, {Maria S} and McSorley, {Emeir M} and Watson, {Gene, E.} and Shamlaye, {Conrad, F.} and JJ Strain and Myers, {Gary, J.} and Davidson, {Philip, W.} and {Van Wijngaarden}, Edwin and Karin Broberg",
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Polyunsaturated fatty acid status and methylmercury exposure are not associated with leukocyte telomere length in mothers or their children in the Seychelles Child Development Study. / Yeates, Alison J.; Thurston, Sally, W,; Li, Huiqi; Mulhern, Maria S; McSorley, Emeir M; Watson, Gene, E.; Shamlaye, Conrad, F.; Strain, JJ; Myers, Gary, J.; Davidson, Philip, W.; Van Wijngaarden, Edwin; Broberg, Karin.

In: Journal of Nutrition, Vol. 147, No. 11, 01.11.2017, p. 2018-2024.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Polyunsaturated fatty acid status and methylmercury exposure are not associated with leukocyte telomere length in mothers or their children in the Seychelles Child Development Study

AU - Yeates, Alison J.

AU - Thurston, Sally, W,

AU - Li, Huiqi

AU - Mulhern, Maria S

AU - McSorley, Emeir M

AU - Watson, Gene, E.

AU - Shamlaye, Conrad, F.

AU - Strain, JJ

AU - Myers, Gary, J.

AU - Davidson, Philip, W.

AU - Van Wijngaarden, Edwin

AU - Broberg, Karin

PY - 2017/11/1

Y1 - 2017/11/1

N2 - ABSTRACTBackground Leukocyte telomere length (TL) is associated with age-related diseases and early mortality, but there is a lack of data on determinants of TL in early life. Evidence suggests that dietary intake of marine n-3 polyunsaturated fatty acids (PUFA) is protective of telomere attrition. Yet the effect of methylmercury (MeHg) exposure, also found in fish, on TL is unknown. Objective The aim of this study was to investigate associations between prenatal PUFA status, MeHg exposure and TL in mothers and children in the Seychelles, where fish consumption is high. Methods Blood samples collected from 229 mothers (at 28wk gestation and delivery) and children (at 5y of age) in the Seychelles Child Development Study Nutrition Cohort 1 were analyzed for PUFA concentrations. Prenatal Hg was measured in maternal hair collected at delivery. Postnatal Hg was also measured in children’s hair samples, using a cumulative metric derived from values obtained at 3-5y of age. Relative TL was measured in blood obtained from mothers at delivery, in cord blood, and in children at 5y of age by quantitative PCR. Linear regression models were used to investigate associations between PUFA status, MeHg exposure and TL.Results Neither prenatal PUFA status or MeHg exposure were associated with TL of the mother or child, nor with TL attrition rate. However a higher prenatal n-6/n-3 PUFA ratio was significantly associated with longer TL in the mothers (β= 0.001, P= 0.048). Child PUFA status and MeHg exposure were not associated with child TL. However greater values of family Hollingshead socioeconomic status (SES) at 9mo of age were significantly associated with longer TL in cord blood (β=0.005, P= 0.03). Conclusions We found no evidence that PUFA status or MeHg exposure are determinants of TL, in either the mother or child. However, our results support the hypothesis that family SES may be associated with child TL.

AB - ABSTRACTBackground Leukocyte telomere length (TL) is associated with age-related diseases and early mortality, but there is a lack of data on determinants of TL in early life. Evidence suggests that dietary intake of marine n-3 polyunsaturated fatty acids (PUFA) is protective of telomere attrition. Yet the effect of methylmercury (MeHg) exposure, also found in fish, on TL is unknown. Objective The aim of this study was to investigate associations between prenatal PUFA status, MeHg exposure and TL in mothers and children in the Seychelles, where fish consumption is high. Methods Blood samples collected from 229 mothers (at 28wk gestation and delivery) and children (at 5y of age) in the Seychelles Child Development Study Nutrition Cohort 1 were analyzed for PUFA concentrations. Prenatal Hg was measured in maternal hair collected at delivery. Postnatal Hg was also measured in children’s hair samples, using a cumulative metric derived from values obtained at 3-5y of age. Relative TL was measured in blood obtained from mothers at delivery, in cord blood, and in children at 5y of age by quantitative PCR. Linear regression models were used to investigate associations between PUFA status, MeHg exposure and TL.Results Neither prenatal PUFA status or MeHg exposure were associated with TL of the mother or child, nor with TL attrition rate. However a higher prenatal n-6/n-3 PUFA ratio was significantly associated with longer TL in the mothers (β= 0.001, P= 0.048). Child PUFA status and MeHg exposure were not associated with child TL. However greater values of family Hollingshead socioeconomic status (SES) at 9mo of age were significantly associated with longer TL in cord blood (β=0.005, P= 0.03). Conclusions We found no evidence that PUFA status or MeHg exposure are determinants of TL, in either the mother or child. However, our results support the hypothesis that family SES may be associated with child TL.

KW - Polyunsaturated fatty acid status

KW - methylmercury exposure

KW - telomere length

KW - pregnancy

KW - maternal infant nutrition

KW - fish consumption

KW - Seychelles Child Development Study

U2 - 10.3945/jn.117.253021

DO - 10.3945/jn.117.253021

M3 - Article

VL - 147

SP - 2018

EP - 2024

JO - Journal of Nutrition

T2 - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 11

ER -