POLYMORPHISMS OF THE ANGIOTENSIN-CONVERTING-ENZYME GENE IN SUBJECTS WHO DIE FROM CORONARY HEART-DISEASE

AE EVANS, O POIRIER, F KEE, L LECERF, E MCCRUM, T FALCONER, J CRANE, DF OROURKE, F CAMBIEN

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    Abstract

    It has been shown that myocardial infarction survivors are more likely to carry an insertion/deletion polymorphism (I/D) of the angiotensin-converting-enzyme (ACE) gene than age-matched population controls. To test whether the association with coronary risk had been under-estimated, the frequency of the ACE I/D was studied in 213 fatal cases of definite and possible myocardial infarction which came to autopsy in the Belfast MONICA Project area. In comparison to controls from the same population, the autopsy cases had an increased frequency of the ACE D allele (p < 0.02). The overall odds ratios were 2.2 for DD vs. II, and 1.8 for ID vs II (test for trends p = 0.01). The findings bear out the hypothesis that the ACE I/D polymorphism is a risk factor for fatal myocardial infarction and sudden cardiac death.
    LanguageEnglish
    Pages211-214
    JournalQuarterly Journal of Medicine
    Volume87
    Issue number4
    Publication statusPublished - Apr 1994

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    Peptidyl-Dipeptidase A
    Coronary Disease
    Myocardial Infarction
    Genes
    Autopsy
    Population Control
    Sudden Cardiac Death
    Survivors
    Alleles
    Odds Ratio
    Population

    Cite this

    EVANS, AE., POIRIER, O., KEE, F., LECERF, L., MCCRUM, E., FALCONER, T., ... CAMBIEN, F. (1994). POLYMORPHISMS OF THE ANGIOTENSIN-CONVERTING-ENZYME GENE IN SUBJECTS WHO DIE FROM CORONARY HEART-DISEASE. Quarterly Journal of Medicine, 87(4), 211-214.
    EVANS, AE ; POIRIER, O ; KEE, F ; LECERF, L ; MCCRUM, E ; FALCONER, T ; CRANE, J ; OROURKE, DF ; CAMBIEN, F. / POLYMORPHISMS OF THE ANGIOTENSIN-CONVERTING-ENZYME GENE IN SUBJECTS WHO DIE FROM CORONARY HEART-DISEASE. In: Quarterly Journal of Medicine. 1994 ; Vol. 87, No. 4. pp. 211-214.
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    abstract = "It has been shown that myocardial infarction survivors are more likely to carry an insertion/deletion polymorphism (I/D) of the angiotensin-converting-enzyme (ACE) gene than age-matched population controls. To test whether the association with coronary risk had been under-estimated, the frequency of the ACE I/D was studied in 213 fatal cases of definite and possible myocardial infarction which came to autopsy in the Belfast MONICA Project area. In comparison to controls from the same population, the autopsy cases had an increased frequency of the ACE D allele (p < 0.02). The overall odds ratios were 2.2 for DD vs. II, and 1.8 for ID vs II (test for trends p = 0.01). The findings bear out the hypothesis that the ACE I/D polymorphism is a risk factor for fatal myocardial infarction and sudden cardiac death.",
    author = "AE EVANS and O POIRIER and F KEE and L LECERF and E MCCRUM and T FALCONER and J CRANE and DF OROURKE and F CAMBIEN",
    year = "1994",
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    EVANS, AE, POIRIER, O, KEE, F, LECERF, L, MCCRUM, E, FALCONER, T, CRANE, J, OROURKE, DF & CAMBIEN, F 1994, 'POLYMORPHISMS OF THE ANGIOTENSIN-CONVERTING-ENZYME GENE IN SUBJECTS WHO DIE FROM CORONARY HEART-DISEASE', Quarterly Journal of Medicine, vol. 87, no. 4, pp. 211-214.

    POLYMORPHISMS OF THE ANGIOTENSIN-CONVERTING-ENZYME GENE IN SUBJECTS WHO DIE FROM CORONARY HEART-DISEASE. / EVANS, AE; POIRIER, O; KEE, F; LECERF, L; MCCRUM, E; FALCONER, T; CRANE, J; OROURKE, DF; CAMBIEN, F.

    In: Quarterly Journal of Medicine, Vol. 87, No. 4, 04.1994, p. 211-214.

    Research output: Contribution to journalArticle

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    N2 - It has been shown that myocardial infarction survivors are more likely to carry an insertion/deletion polymorphism (I/D) of the angiotensin-converting-enzyme (ACE) gene than age-matched population controls. To test whether the association with coronary risk had been under-estimated, the frequency of the ACE I/D was studied in 213 fatal cases of definite and possible myocardial infarction which came to autopsy in the Belfast MONICA Project area. In comparison to controls from the same population, the autopsy cases had an increased frequency of the ACE D allele (p < 0.02). The overall odds ratios were 2.2 for DD vs. II, and 1.8 for ID vs II (test for trends p = 0.01). The findings bear out the hypothesis that the ACE I/D polymorphism is a risk factor for fatal myocardial infarction and sudden cardiac death.

    AB - It has been shown that myocardial infarction survivors are more likely to carry an insertion/deletion polymorphism (I/D) of the angiotensin-converting-enzyme (ACE) gene than age-matched population controls. To test whether the association with coronary risk had been under-estimated, the frequency of the ACE I/D was studied in 213 fatal cases of definite and possible myocardial infarction which came to autopsy in the Belfast MONICA Project area. In comparison to controls from the same population, the autopsy cases had an increased frequency of the ACE D allele (p < 0.02). The overall odds ratios were 2.2 for DD vs. II, and 1.8 for ID vs II (test for trends p = 0.01). The findings bear out the hypothesis that the ACE I/D polymorphism is a risk factor for fatal myocardial infarction and sudden cardiac death.

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    EVANS AE, POIRIER O, KEE F, LECERF L, MCCRUM E, FALCONER T et al. POLYMORPHISMS OF THE ANGIOTENSIN-CONVERTING-ENZYME GENE IN SUBJECTS WHO DIE FROM CORONARY HEART-DISEASE. Quarterly Journal of Medicine. 1994 Apr;87(4):211-214.