Polymorphisms in ATP-binding cassette transporters associated with maternal methylmercury disposition and infant neurodevelopment in mother-infant pairs in the Seychelles Child Development Study.

Karin Engstrom, Tanzy M Love, Gene E Watson, Grazyna Zareba, Alison J. Yeates, Karin Wahlberg, Ayman Alhamdow, Sally W Thurston, Maria S. Mulhern, Emeir M. McSorley, JJ Strain, Philip W Davidson, Conrad F Shamlaye, Gary J Myers, Matthew D Rand, Edwin van Wijngaarden, Karin Broberg

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Abstract

Background: ATP-binding cassette (ABC) transporters have been associated with methylmercury (MeHg) toxicity in experimental animal models.Aims: To evaluate the association of single nucleotide polymorphisms (SNPs) in maternal ABC transporter genes with 1) maternal hair MeHg concentrations during pregnancy and 2) child neurodevelopmental outcomes.Materials and methods: Nutrition Cohort 2 (NC2) is an observational mother-child cohort recruited in the Republic of Seychelles from 2008-2011. Total mercury (Hg) was measured in maternal hair growing during pregnancy as a biomarker for prenatal MeHg exposure (N=1313) (mean 3.9 ppm). Infants completed developmental assessments by Bayley Scales of Infant Development II (BSID-II) at 20 months of age (N=1331). Genotyping for fifteen SNPs in ABCC1, ABCC2 and ABCB1 was performed for the mothers. Results: Seven of fifteen ABC SNPs (ABCC1 rs11075290, rs212093, and rs215088; ABCC2 rs717620; ABCB1 rs10276499, rs1202169, and rs2032582) were associated with concentrations of maternal hair Hg (p
Original languageEnglish
Pages (from-to)224-229
Number of pages5
JournalEnvironment International
Volume94
Early online date2 Jun 2016
DOIs
Publication statusPublished - Sep 2016

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child development
methylmercury
hair
polymorphism
pregnancy
biomarker
nutrition
toxicity
gene
animal
infant

Keywords

  • ABC transporter
  • MRP1
  • MRP2
  • MDR1
  • p-glycoprotein
  • neurodevelopment

Cite this

Engstrom, Karin ; Love, Tanzy M ; Watson, Gene E ; Zareba, Grazyna ; Yeates, Alison J. ; Wahlberg, Karin ; Alhamdow, Ayman ; Thurston, Sally W ; Mulhern, Maria S. ; McSorley, Emeir M. ; Strain, JJ ; Davidson, Philip W ; Shamlaye, Conrad F ; Myers, Gary J ; Rand, Matthew D ; van Wijngaarden, Edwin ; Broberg, Karin. / Polymorphisms in ATP-binding cassette transporters associated with maternal methylmercury disposition and infant neurodevelopment in mother-infant pairs in the Seychelles Child Development Study. In: Environment International. 2016 ; Vol. 94. pp. 224-229.
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abstract = "Background: ATP-binding cassette (ABC) transporters have been associated with methylmercury (MeHg) toxicity in experimental animal models.Aims: To evaluate the association of single nucleotide polymorphisms (SNPs) in maternal ABC transporter genes with 1) maternal hair MeHg concentrations during pregnancy and 2) child neurodevelopmental outcomes.Materials and methods: Nutrition Cohort 2 (NC2) is an observational mother-child cohort recruited in the Republic of Seychelles from 2008-2011. Total mercury (Hg) was measured in maternal hair growing during pregnancy as a biomarker for prenatal MeHg exposure (N=1313) (mean 3.9 ppm). Infants completed developmental assessments by Bayley Scales of Infant Development II (BSID-II) at 20 months of age (N=1331). Genotyping for fifteen SNPs in ABCC1, ABCC2 and ABCB1 was performed for the mothers. Results: Seven of fifteen ABC SNPs (ABCC1 rs11075290, rs212093, and rs215088; ABCC2 rs717620; ABCB1 rs10276499, rs1202169, and rs2032582) were associated with concentrations of maternal hair Hg (p",
keywords = "ABC transporter, MRP1, MRP2, MDR1, p-glycoprotein, neurodevelopment",
author = "Karin Engstrom and Love, {Tanzy M} and Watson, {Gene E} and Grazyna Zareba and Yeates, {Alison J.} and Karin Wahlberg and Ayman Alhamdow and Thurston, {Sally W} and Mulhern, {Maria S.} and McSorley, {Emeir M.} and JJ Strain and Davidson, {Philip W} and Shamlaye, {Conrad F} and Myers, {Gary J} and Rand, {Matthew D} and {van Wijngaarden}, Edwin and Karin Broberg",
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Polymorphisms in ATP-binding cassette transporters associated with maternal methylmercury disposition and infant neurodevelopment in mother-infant pairs in the Seychelles Child Development Study. / Engstrom, Karin; Love, Tanzy M; Watson, Gene E; Zareba, Grazyna; Yeates, Alison J.; Wahlberg, Karin; Alhamdow, Ayman; Thurston, Sally W; Mulhern, Maria S.; McSorley, Emeir M.; Strain, JJ; Davidson, Philip W; Shamlaye, Conrad F; Myers, Gary J; Rand, Matthew D; van Wijngaarden, Edwin; Broberg, Karin.

In: Environment International, Vol. 94, 09.2016, p. 224-229.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Polymorphisms in ATP-binding cassette transporters associated with maternal methylmercury disposition and infant neurodevelopment in mother-infant pairs in the Seychelles Child Development Study.

AU - Engstrom, Karin

AU - Love, Tanzy M

AU - Watson, Gene E

AU - Zareba, Grazyna

AU - Yeates, Alison J.

AU - Wahlberg, Karin

AU - Alhamdow, Ayman

AU - Thurston, Sally W

AU - Mulhern, Maria S.

AU - McSorley, Emeir M.

AU - Strain, JJ

AU - Davidson, Philip W

AU - Shamlaye, Conrad F

AU - Myers, Gary J

AU - Rand, Matthew D

AU - van Wijngaarden, Edwin

AU - Broberg, Karin

PY - 2016/9

Y1 - 2016/9

N2 - Background: ATP-binding cassette (ABC) transporters have been associated with methylmercury (MeHg) toxicity in experimental animal models.Aims: To evaluate the association of single nucleotide polymorphisms (SNPs) in maternal ABC transporter genes with 1) maternal hair MeHg concentrations during pregnancy and 2) child neurodevelopmental outcomes.Materials and methods: Nutrition Cohort 2 (NC2) is an observational mother-child cohort recruited in the Republic of Seychelles from 2008-2011. Total mercury (Hg) was measured in maternal hair growing during pregnancy as a biomarker for prenatal MeHg exposure (N=1313) (mean 3.9 ppm). Infants completed developmental assessments by Bayley Scales of Infant Development II (BSID-II) at 20 months of age (N=1331). Genotyping for fifteen SNPs in ABCC1, ABCC2 and ABCB1 was performed for the mothers. Results: Seven of fifteen ABC SNPs (ABCC1 rs11075290, rs212093, and rs215088; ABCC2 rs717620; ABCB1 rs10276499, rs1202169, and rs2032582) were associated with concentrations of maternal hair Hg (p

AB - Background: ATP-binding cassette (ABC) transporters have been associated with methylmercury (MeHg) toxicity in experimental animal models.Aims: To evaluate the association of single nucleotide polymorphisms (SNPs) in maternal ABC transporter genes with 1) maternal hair MeHg concentrations during pregnancy and 2) child neurodevelopmental outcomes.Materials and methods: Nutrition Cohort 2 (NC2) is an observational mother-child cohort recruited in the Republic of Seychelles from 2008-2011. Total mercury (Hg) was measured in maternal hair growing during pregnancy as a biomarker for prenatal MeHg exposure (N=1313) (mean 3.9 ppm). Infants completed developmental assessments by Bayley Scales of Infant Development II (BSID-II) at 20 months of age (N=1331). Genotyping for fifteen SNPs in ABCC1, ABCC2 and ABCB1 was performed for the mothers. Results: Seven of fifteen ABC SNPs (ABCC1 rs11075290, rs212093, and rs215088; ABCC2 rs717620; ABCB1 rs10276499, rs1202169, and rs2032582) were associated with concentrations of maternal hair Hg (p

KW - ABC transporter

KW - MRP1

KW - MRP2

KW - MDR1

KW - p-glycoprotein

KW - neurodevelopment

UR - https://pure.ulster.ac.uk/en/publications/polymorphisms-in-atp-binding-cassette-transporters-associated-wit-3

U2 - 10.1016/j.envint.2016.05.027

DO - 10.1016/j.envint.2016.05.027

M3 - Article

VL - 94

SP - 224

EP - 229

JO - Environment International

JF - Environment International

SN - 0160-4120

ER -