Polymorphisms in ATP-binding cassette transporters associated with maternal methylmercury disposition and infant neurodevelopment in mother-infant pairs in the Seychelles Child Development Study.

Karin Engstrom, Tanzy M Love, Gene E Watson, Grazyna Zareba, Alison J. Yeates, Karin Wahlberg, Ayman Alhamdow, Sally W Thurston, Maria S. Mulhern, Emeir M. McSorley, JJ Strain, Philip W Davidson, Conrad F Shamlaye, Gary J Myers, Matthew D Rand, Edwin van Wijngaarden, Karin Broberg

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Abstract

Background: ATP-binding cassette (ABC) transporters have been associated with methylmercury (MeHg) toxicity in experimental animal models.Aims: To evaluate the association of single nucleotide polymorphisms (SNPs) in maternal ABC transporter genes with 1) maternal hair MeHg concentrations during pregnancy and 2) child neurodevelopmental outcomes.Materials and methods: Nutrition Cohort 2 (NC2) is an observational mother-child cohort recruited in the Republic of Seychelles from 2008-2011. Total mercury (Hg) was measured in maternal hair growing during pregnancy as a biomarker for prenatal MeHg exposure (N=1313) (mean 3.9 ppm). Infants completed developmental assessments by Bayley Scales of Infant Development II (BSID-II) at 20 months of age (N=1331). Genotyping for fifteen SNPs in ABCC1, ABCC2 and ABCB1 was performed for the mothers. Results: Seven of fifteen ABC SNPs (ABCC1 rs11075290, rs212093, and rs215088; ABCC2 rs717620; ABCB1 rs10276499, rs1202169, and rs2032582) were associated with concentrations of maternal hair Hg (p
Original languageEnglish
Pages (from-to)224-229
Number of pages5
JournalEnvironment International
Volume94
Early online date2 Jun 2016
DOIs
Publication statusPublished - Sep 2016

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Keywords

  • ABC transporter
  • MRP1
  • MRP2
  • MDR1
  • p-glycoprotein
  • neurodevelopment

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