Polymeric microbubbles as delivery vehicles for sensitizers in sonodynamic therapy

C. McEwan, Colin Fowley, N. Nomikou, Bridgeen McCaughan, AP McHale, J Callan

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Microbubbles (MBs) have recently emerged as promising delivery vehicles for sensitizer drugs in sonodynamic therapy (SDT). The ability to selectively destroy the MB and activate the sensitizer using an external ultrasound trigger could provide a minimally invasive and highly targeted therapy. While lipid MBs have been approved for use as contrast agents in diagnostic ultrasound, the attachment of sensitizer drugs to their surface results in a significant reduction in particle stability. In this Article, we prepare both lipid and polymer (PLGA) MBs with rose bengal attached to their surface and demonstrate that PLGA MB conjugates are significantly more stable than their lipid counterparts. In addition, the improved stability offered by the PLGA shell does not hinder their selective destruction using therapeutically acceptable ultrasound intensities. Furthermore, we demonstrate that treatment of ectopic human tumors (BxPC-3) in mice with the PLGA MB-rose bengal conjugate and ultrasound reduced tumor volume by 34 4 days after treatment while tumors treated with the conjugate alone increased in volume by 48 over the same time period. Therefore, PLGA MBs may offer a more stable alternative to lipid MBs for the site specific delivery of sensitizers in SDT. (Graph Presented). © 2014 American Chemical Society.
LanguageEnglish
Pages14926-14930
JournalLangmuir
Volume30
Issue number49
DOIs
Publication statusPublished - 2014

Fingerprint

Microbubbles
Lipids
Rose Bengal
Therapeutics
Tumor Burden
Pharmaceutical Preparations
Contrast Media
Ultrasonography
Neoplasms
Polymers
polylactic acid-polyglycolic acid copolymer

Keywords

  • Copolymers
  • Diagnosis
  • Polymers
  • Tumors
  • Ultrasonics
  • Delivery vehicle
  • Diagnostic ultrasound
  • Minimally invasive
  • Particle stability
  • Selective destruction
  • Selectively destroy
  • Sonodynamic therapy
  • Ultrasound intensity
  • Drug therapy
  • coumarin
  • coumarin derivative
  • animal
  • cell line
  • cell survival
  • chemical structure
  • drug delivery system
  • female
  • HeLa cell line
  • human
  • microbubble
  • mouse
  • ultrasound
  • ultrasound therapy
  • Uterine Neoplasms
  • Animals
  • Cell Line
  • Cell Survival
  • Coumarins
  • Drug Delivery Systems
  • Female
  • HeLa Cells
  • Humans
  • Mice
  • Microbubbles
  • Molecular Structure
  • Ultrasonic Therapy

Cite this

McEwan, C. ; Fowley, Colin ; Nomikou, N. ; McCaughan, Bridgeen ; McHale, AP ; Callan, J. / Polymeric microbubbles as delivery vehicles for sensitizers in sonodynamic therapy. In: Langmuir. 2014 ; Vol. 30, No. 49. pp. 14926-14930.
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abstract = "Microbubbles (MBs) have recently emerged as promising delivery vehicles for sensitizer drugs in sonodynamic therapy (SDT). The ability to selectively destroy the MB and activate the sensitizer using an external ultrasound trigger could provide a minimally invasive and highly targeted therapy. While lipid MBs have been approved for use as contrast agents in diagnostic ultrasound, the attachment of sensitizer drugs to their surface results in a significant reduction in particle stability. In this Article, we prepare both lipid and polymer (PLGA) MBs with rose bengal attached to their surface and demonstrate that PLGA MB conjugates are significantly more stable than their lipid counterparts. In addition, the improved stability offered by the PLGA shell does not hinder their selective destruction using therapeutically acceptable ultrasound intensities. Furthermore, we demonstrate that treatment of ectopic human tumors (BxPC-3) in mice with the PLGA MB-rose bengal conjugate and ultrasound reduced tumor volume by 34 4 days after treatment while tumors treated with the conjugate alone increased in volume by 48 over the same time period. Therefore, PLGA MBs may offer a more stable alternative to lipid MBs for the site specific delivery of sensitizers in SDT. (Graph Presented). {\circledC} 2014 American Chemical Society.",
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Polymeric microbubbles as delivery vehicles for sensitizers in sonodynamic therapy. / McEwan, C.; Fowley, Colin; Nomikou, N.; McCaughan, Bridgeen; McHale, AP; Callan, J.

In: Langmuir, Vol. 30, No. 49, 2014, p. 14926-14930.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Polymeric microbubbles as delivery vehicles for sensitizers in sonodynamic therapy

AU - McEwan, C.

AU - Fowley, Colin

AU - Nomikou, N.

AU - McCaughan, Bridgeen

AU - McHale, AP

AU - Callan, J

N1 - cited By 2

PY - 2014

Y1 - 2014

N2 - Microbubbles (MBs) have recently emerged as promising delivery vehicles for sensitizer drugs in sonodynamic therapy (SDT). The ability to selectively destroy the MB and activate the sensitizer using an external ultrasound trigger could provide a minimally invasive and highly targeted therapy. While lipid MBs have been approved for use as contrast agents in diagnostic ultrasound, the attachment of sensitizer drugs to their surface results in a significant reduction in particle stability. In this Article, we prepare both lipid and polymer (PLGA) MBs with rose bengal attached to their surface and demonstrate that PLGA MB conjugates are significantly more stable than their lipid counterparts. In addition, the improved stability offered by the PLGA shell does not hinder their selective destruction using therapeutically acceptable ultrasound intensities. Furthermore, we demonstrate that treatment of ectopic human tumors (BxPC-3) in mice with the PLGA MB-rose bengal conjugate and ultrasound reduced tumor volume by 34 4 days after treatment while tumors treated with the conjugate alone increased in volume by 48 over the same time period. Therefore, PLGA MBs may offer a more stable alternative to lipid MBs for the site specific delivery of sensitizers in SDT. (Graph Presented). © 2014 American Chemical Society.

AB - Microbubbles (MBs) have recently emerged as promising delivery vehicles for sensitizer drugs in sonodynamic therapy (SDT). The ability to selectively destroy the MB and activate the sensitizer using an external ultrasound trigger could provide a minimally invasive and highly targeted therapy. While lipid MBs have been approved for use as contrast agents in diagnostic ultrasound, the attachment of sensitizer drugs to their surface results in a significant reduction in particle stability. In this Article, we prepare both lipid and polymer (PLGA) MBs with rose bengal attached to their surface and demonstrate that PLGA MB conjugates are significantly more stable than their lipid counterparts. In addition, the improved stability offered by the PLGA shell does not hinder their selective destruction using therapeutically acceptable ultrasound intensities. Furthermore, we demonstrate that treatment of ectopic human tumors (BxPC-3) in mice with the PLGA MB-rose bengal conjugate and ultrasound reduced tumor volume by 34 4 days after treatment while tumors treated with the conjugate alone increased in volume by 48 over the same time period. Therefore, PLGA MBs may offer a more stable alternative to lipid MBs for the site specific delivery of sensitizers in SDT. (Graph Presented). © 2014 American Chemical Society.

KW - Copolymers

KW - Diagnosis

KW - Polymers

KW - Tumors

KW - Ultrasonics

KW - Delivery vehicle

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KW - Minimally invasive

KW - Particle stability

KW - Selective destruction

KW - Selectively destroy

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KW - ultrasound therapy

KW - Uterine Neoplasms

KW - Animals

KW - Cell Line

KW - Cell Survival

KW - Coumarins

KW - Drug Delivery Systems

KW - Female

KW - HeLa Cells

KW - Humans

KW - Mice

KW - Microbubbles

KW - Molecular Structure

KW - Ultrasonic Therapy

U2 - 10.1021/la503929c

DO - 10.1021/la503929c

M3 - Article

VL - 30

SP - 14926

EP - 14930

JO - Langmuir

T2 - Langmuir

JF - Langmuir

SN - 0743-7463

IS - 49

ER -