POLYMER DEMIXED COATINGS FOR PATIENT-SPECIFIC SENSING WITHIN A WHOLE BLOOD ASSAY

Research output: Contribution to conferencePaper

Abstract

Von Willebrand’s disease (vWD) is the most common bleeding disorder, with approximately 1% of people affected globally [1]. It is characterised by a deficiency in the blood protein von Willebrand factor (vWF) [2]. The assessment of vWF in conjunction with platelet interaction is essential in understanding vWF activity in both healthy individuals and those with vWD. The fabrication of micro- and nanotopographies can facilitate blood-sensing technologies [3] within microfluidic flow chamber devices.
The most modern version of such devices, the dynamic platelet function assay (DPFA) facilitates dynamic blood flow at shear rates equivalent to arterial blood flow to better mimic the in vivo conditions [4]. However, the DPFA lacks specificity, due to the use of the endogenous vWF.
In this study, a range of polymer demixed surfaces previously studied [5] have been prepared from PMMA/PS and PMMA/PS + PS microsphere solutions under ambient conditions and incorporated within the flow chamber of the DPFA to investigate patient-specific protein and platelet binding. Furthermore, platelet kinetics have been investigated to determine any significant differences in platelet binding across substrate topographies.
Original languageEnglish
Pages46
Number of pages1
Publication statusPublished online - 20 Jun 2023
EventUnited Kingdom Society of Biomaterials Annual Conference: UKSB2023 - Ulster University, Belfast, United Kingdom
Duration: 20 Jun 202321 Jun 2023
Conference number: 23
https://www.uksb.org.uk/wp-content/uploads/2023/06/Abstract-Book-Programme.pdf

Conference

ConferenceUnited Kingdom Society of Biomaterials Annual Conference
Country/TerritoryUnited Kingdom
CityBelfast
Period20/06/2321/06/23
Internet address

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