Polyherbal renal tea extract shows anti-inflammatory and antioxidant effects against gentamicin-induced nephrotoxicity in guinea pigs

Joshua Asante, Aliu Moomin, Michael Ofori, Tetteh Jude, Paa Kofi Tawiah Adu-Gyamfi, Maryna Yeshuna, Charles Kwaku Benneh, Charles Ansah, Kwesi Boadu Mensah

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Abstract

Renal diseases pose a tremendous economic burden worldwide, and the only treatment options are renal transplantation and dialysis, which remain unaffordable to low-income people. This study evaluated the potential of polyherbal renal tea extract (RTE) as a remedy for kidney disease using a gentamicin-induced kidney damage model in guinea pigs. Polyherbal renal tea was purchased from the market and extracted with 70% ethanol. RTE phytochemicals were screened qualitatively and chemoprofiled by High-performance liquid chromatography. Acute and sub-acute toxicity studies on RTE were carried out. To investigate the possible effects of RTE, groups of animals received either gentamicin intraperitoneally alone or in combination with oral administration of RTE (200, 600 or 1000 mg/kg/day) for 14 days. On day 15, the biochemical and renal markers of damage and inflammation were assessed. The RTE caused no significant changes in blood biochemistry or renal histomorphology, with LD50 >5000 mg/kg. Significantly (p
Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalEgyptian Journal of Basic and Applied Sciences
Volume12
Issue number1
Early online date31 Dec 2024
DOIs
Publication statusPublished online - 31 Dec 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Data Access Statement

The data can be made available from the corre-sponding author on reasonable request.

Keywords

  • gentamicin toxicity
  • kidney damage
  • nephroprotective
  • anti-inflammatory
  • Antioxidant enzymes
  • polyherbal renal tea

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