Polygenic expression of somatostatin in lamprey

Stacia A. Sower; Y. C. Chiang; J. M. Conlon

doi:10.1016/0196-9781(94)90184-8

Polygenic expression of somatostatin in lamprey

Stacia A. Sower
, Y. C. Chiang
, J. M. Conlon

School of Biomedical Sciences

University of New Hampshire

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Previous studies have led to the identification of three biosynthetically related molecular forms of somatostatin (somatostatin-14, -34 and -37) from the pancreas of the sea lamprey (Petromyzon marinus). We have now isolated from the brain of the same species a second form of somatostatin-14 that is identical to mammalian somatostatin-14 and differs from lamprey pancreatic somatostatin-14 by the substitution Ser¹² to Thr. Larger forms of somatostatin were not identified in lamprey brain in this study. These data suggest that the two molecular forms of lamprey somatostatin-14 are the products of different genes that are expressed in a tissue-specific manner.

Original language	English
Pages (from-to)	151-154
Number of pages	4
Journal	Peptides
Volume	15
Issue number	1
DOIs	https://doi.org/10.1016/0196-9781(94)90184-8
Publication status	Published (in print/issue) - Jan 1994

Funding

We thank Thomas Bolduc and Mary Jane James for their help during sampling of lamprey brains. We thank Drs. J. A. King and R. P. Millar for lamprey GnRH antisera. This work was supported by National Science Foundation Grants (#DCB-9004332 and DCB-8904919 to S.A.S.; DCB-9117387 to J.M.C.) and the Great Lakes Fishery Commission (S.A.S.).

Funders	Funder number
National Science Foundation	DCB-9117387, -9004332, DCB-8904919

Keywords

Agnathan
Lamprey brain
Posttranslational processing
Somatostatin

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10.1016/0196-9781(94)90184-8

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abstract = "Previous studies have led to the identification of three biosynthetically related molecular forms of somatostatin (somatostatin-14, -34 and -37) from the pancreas of the sea lamprey (Petromyzon marinus). We have now isolated from the brain of the same species a second form of somatostatin-14 that is identical to mammalian somatostatin-14 and differs from lamprey pancreatic somatostatin-14 by the substitution Ser12 to Thr. Larger forms of somatostatin were not identified in lamprey brain in this study. These data suggest that the two molecular forms of lamprey somatostatin-14 are the products of different genes that are expressed in a tissue-specific manner.",

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AB - Previous studies have led to the identification of three biosynthetically related molecular forms of somatostatin (somatostatin-14, -34 and -37) from the pancreas of the sea lamprey (Petromyzon marinus). We have now isolated from the brain of the same species a second form of somatostatin-14 that is identical to mammalian somatostatin-14 and differs from lamprey pancreatic somatostatin-14 by the substitution Ser12 to Thr. Larger forms of somatostatin were not identified in lamprey brain in this study. These data suggest that the two molecular forms of lamprey somatostatin-14 are the products of different genes that are expressed in a tissue-specific manner.

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Polygenic expression of somatostatin in lamprey

Abstract

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Keywords

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