Polycaprolactone/multi-walled carbon nanotube nerve guidance conduits with tunable channels fabricated via novel extrusion-stretching method for peripheral nerve repair

Longfei Zhang, Renyuan Sun, Baolin Wang, Yuna Lang, Ming-Wei Chang

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Abstract

Multi-channeled nerve guidance conduit is a prospective way to repair peripheral nerve injury, which is still difficult to be fabricated. A novel extrusion-stretching method was utilized in this study to produce multi-walled carbon nanotubes (MWCNTs) loaded multi-channeled nerve conduits with improved flexibility and versatility. The channels and geography of the conduits were tunable. The results showed that the mechanical properties of the multi-channeled nerve conduits were suitable for peripheral nerve restoration. MWCNTs increased the biocompatibility of the multi-channeled nerve conduits. This study proved that the MWCNTs loaded multi-channeled produced by extrusion-stretching method have great potential to repair peripheral nerve injury.
Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
Volume73
Issue number8
Early online date6 Apr 2023
DOIs
Publication statusPublished online - 6 Apr 2023

Bibliographical note

Publisher Copyright:
© 2023 Taylor & Francis Group, LLC.

Keywords

  • Polymers and Plastics
  • General Chemical Engineering
  • Analytical Chemistry
  • Extrusion-stretching method
  • multi-channels
  • MWCNTs
  • peripheral nerve repair
  • nerve guidance conduits

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