Point-of-care diagnostics for sepsis using clinical biomarkers and microfluidic technology

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Abstract

Sepsis is a life-threatening immune response which is caused by a wide variety of sources and is a leading cause of mortality globally. Rapid diagnosis and appropriate antibiotic treatment are critical for successful patient outcomes; however, current molecular diagnostic techniques are time-consuming, costly and require trained personnel. Additionally, there is a lack of rapid point-of-care (POC) devices available for sepsis detection despite the urgent requirements in emergency departments and low-resource areas. Recent advances have been made toward developing a POC test for early sepsis detection that will be more rapid and accurate compared to conventional techniques. Within this context, this review discusses the use of current and novel biomarkers for early sepsis diagnosis using microfluidics devices for POC testing.
Original languageEnglish
Article number115181
Pages (from-to)1-13
Number of pages14
JournalBiosensors and Bioelectronics
Volume227
Early online date24 Feb 2023
DOIs
Publication statusPublished online - 24 Feb 2023

Bibliographical note

Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

Keywords

  • Sepsis biomarkers
  • Sepsis diagnostics
  • Microfluidic technology
  • Microfluidic materials
  • Point-of-care testing

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