Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae

Vanessa Devine, David Cleary, Denise Morris, Karen Osman, Rebecca A Gladstone, Saul N Faust, Stuart C Clarke

Research output: Contribution to journalArticle

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Abstract

The implementation of pneumococcal conjugate vaccines (PCVs) has led to a decline in vaccine-type disease. However, there is evidence that the epidemiology of non-typeable Haemophilus influenzae (NTHi) carriage and disease can be altered as a consequence of PCV introduction. We explored the epidemiological shifts in NTHi carriage using whole genome sequencing over a 5-year period that included PCV13 replacement of PCV7 in the UK's National Immunization Programme in 2010. Between 2008/09 and 2012/13 (October to March), nasopharyngeal swabs were taken from children <5 years of age. Significantly increased carriage post-PCV13 was observed and lineage-specific associations with Streptococcus pneumoniae were seen before but not after PCV13 introduction. NTHi were characterized into 11 discrete, temporally stable lineages, congruent with current knowledge regarding the clonality of NTHi. The increased carriage could not be linked to the expansion of a particular clone and different co-carriage dynamics were seen before PCV13 implementation when NTHi co-carried with vaccine serotype pneumococci. In summary, PCV13 introduction has been shown to have an indirect effect on NTHi epidemiology and there exists both negative and positive, distinct associations between pneumococci and NTHi. This should be considered when evaluating the impacts of pneumococcal vaccine design and policy.
LanguageEnglish
Article numberVolume 4, Issue 9
Pages1-13
Number of pages13
JournalMicrobial Genomics
Volume4
Issue number9
Publication statusPublished - 4 Sep 2018

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Metagenomics
Pneumococcal Vaccines
Haemophilus influenzae
Streptococcus pneumoniae
Conjugate Vaccines
Epidemiology
Vaccines
Immunization Programs
Clone Cells
Genome

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Devine, V., Cleary, D., Morris, D., Osman, K., Gladstone, R. A., Faust, S. N., & Clarke, S. C. (2018). Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae. 4(9), 1-13. [Volume 4, Issue 9].
Devine, Vanessa ; Cleary, David ; Morris, Denise ; Osman, Karen ; Gladstone, Rebecca A ; Faust, Saul N ; Clarke, Stuart C. / Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae. 2018 ; Vol. 4, No. 9. pp. 1-13.
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Devine, V, Cleary, D, Morris, D, Osman, K, Gladstone, RA, Faust, SN & Clarke, SC 2018, 'Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae', vol. 4, no. 9, Volume 4, Issue 9, pp. 1-13.

Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae. / Devine, Vanessa; Cleary, David; Morris, Denise; Osman, Karen; Gladstone, Rebecca A; Faust, Saul N; Clarke, Stuart C.

Vol. 4, No. 9, Volume 4, Issue 9, 04.09.2018, p. 1-13.

Research output: Contribution to journalArticle

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AU - Devine, Vanessa

AU - Cleary, David

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AU - Clarke, Stuart C

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AB - The implementation of pneumococcal conjugate vaccines (PCVs) has led to a decline in vaccine-type disease. However, there is evidence that the epidemiology of non-typeable Haemophilus influenzae (NTHi) carriage and disease can be altered as a consequence of PCV introduction. We explored the epidemiological shifts in NTHi carriage using whole genome sequencing over a 5-year period that included PCV13 replacement of PCV7 in the UK's National Immunization Programme in 2010. Between 2008/09 and 2012/13 (October to March), nasopharyngeal swabs were taken from children <5 years of age. Significantly increased carriage post-PCV13 was observed and lineage-specific associations with Streptococcus pneumoniae were seen before but not after PCV13 introduction. NTHi were characterized into 11 discrete, temporally stable lineages, congruent with current knowledge regarding the clonality of NTHi. The increased carriage could not be linked to the expansion of a particular clone and different co-carriage dynamics were seen before PCV13 implementation when NTHi co-carried with vaccine serotype pneumococci. In summary, PCV13 introduction has been shown to have an indirect effect on NTHi epidemiology and there exists both negative and positive, distinct associations between pneumococci and NTHi. This should be considered when evaluating the impacts of pneumococcal vaccine design and policy.

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Devine V, Cleary D, Morris D, Osman K, Gladstone RA, Faust SN et al. Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae. 2018 Sep 4;4(9):1-13. Volume 4, Issue 9.