Plumbagin: A New Route to the Electroanalytical Determination of Cystine

M Damle, L Newton, R Leslie, J Davis

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The interaction between 5-hydroxy-1,4-naphthoquinone and cysteine was found to give a clearly resolved voltammetric signature that could be used as an electrochemical assay for the thiol. A structure-function study assessed the nature of the resulting voltammetric profile and the highly selective response to cysteine. The translation of the system as the basis of an assay for the determination of cystine was investigated using mercaptopropanol as the in situ reducing agent. The lack of response to the latter and high recovery performance of the label opens up a new direction for the one pot, mercury free determination of cystine.
LanguageEnglish
Pages2491-2495
JournalElectroanalysis
Volume22
Publication statusPublished - 1 Nov 2010

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Cystine
Cysteine
Assays
Reducing Agents
Mercury
Sulfhydryl Compounds
Labels
Recovery
plumbagin
Direction compound
juglone

Cite this

Damle, M ; Newton, L ; Leslie, R ; Davis, J. / Plumbagin: A New Route to the Electroanalytical Determination of Cystine. In: Electroanalysis. 2010 ; Vol. 22. pp. 2491-2495.
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Damle, M, Newton, L, Leslie, R & Davis, J 2010, 'Plumbagin: A New Route to the Electroanalytical Determination of Cystine', Electroanalysis, vol. 22, pp. 2491-2495.

Plumbagin: A New Route to the Electroanalytical Determination of Cystine. / Damle, M; Newton, L; Leslie, R; Davis, J.

In: Electroanalysis, Vol. 22, 01.11.2010, p. 2491-2495.

Research output: Contribution to journalArticle

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