We have investigated the effect of changes in microstructure, surface energy, surface charge condition and electronic conduction on the interaction of human platelets with silicon modified hydrogenated amorphous carbon films (a-C:H:Si or Si-DLC). Results based on Raman spectroscopy, Scanning electron microscopy, X-ray photo-electronspectroscopy, surface energy measurements, electrical resistivity, contact potential difference, and thermal annealing indicates a correlation between some of the measured values and the interaction of the films with human blood platelets. Statistical analysis of platelet aggregation on the films using the Student's t-test indicated differences between platelet aggregation on the modified films compared to the as-deposited film at a p-value of < 0.05. (C) 2003 Elsevier Ltd. All rights reserved.
- Raman spectroscopy
- contact angle/surface energy
- work function/semi-conduction
- human platelet aggregation
Okpalugo, TIT., Ogwu, AA., Maguire, PD., & McLaughlin, JAD. (2004). Platelet adhesion on silicon modified hydrogenated amorphous carbon films. Biomaterials, 25(2), 239-245. https://doi.org/10.1016/S0142-9612(03)00494-0