Platelet adhesion on silicon modified hydrogenated amorphous carbon films

TIT Okpalugo, AA Ogwu, PD Maguire, JAD McLaughlin

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

We have investigated the effect of changes in microstructure, surface energy, surface charge condition and electronic conduction on the interaction of human platelets with silicon modified hydrogenated amorphous carbon films (a-C:H:Si or Si-DLC). Results based on Raman spectroscopy, Scanning electron microscopy, X-ray photo-electronspectroscopy, surface energy measurements, electrical resistivity, contact potential difference, and thermal annealing indicates a correlation between some of the measured values and the interaction of the films with human blood platelets. Statistical analysis of platelet aggregation on the films using the Student's t-test indicated differences between platelet aggregation on the modified films compared to the as-deposited film at a p-value of < 0.05. (C) 2003 Elsevier Ltd. All rights reserved.
LanguageEnglish
Pages239-245
JournalBiomaterials
Volume25
Issue number2
DOIs
Publication statusPublished - Jan 2004

Fingerprint

Carbon films
Amorphous carbon
Silicon
Amorphous films
Platelets
Platelet Aggregation
Blood Platelets
Carbon
Adhesion
Raman Spectrum Analysis
Interfacial energy
Electron Scanning Microscopy
Agglomeration
Hot Temperature
X-Rays
Students
Electric power measurement
Surface measurement
Surface charge
Raman spectroscopy

Keywords

  • Si-DLC
  • Raman spectroscopy
  • haemocompatibility
  • contact angle/surface energy
  • work function/semi-conduction
  • human platelet aggregation

Cite this

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Platelet adhesion on silicon modified hydrogenated amorphous carbon films. / Okpalugo, TIT; Ogwu, AA; Maguire, PD; McLaughlin, JAD.

In: Biomaterials, Vol. 25, No. 2, 01.2004, p. 239-245.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Platelet adhesion on silicon modified hydrogenated amorphous carbon films

AU - Okpalugo, TIT

AU - Ogwu, AA

AU - Maguire, PD

AU - McLaughlin, JAD

PY - 2004/1

Y1 - 2004/1

N2 - We have investigated the effect of changes in microstructure, surface energy, surface charge condition and electronic conduction on the interaction of human platelets with silicon modified hydrogenated amorphous carbon films (a-C:H:Si or Si-DLC). Results based on Raman spectroscopy, Scanning electron microscopy, X-ray photo-electronspectroscopy, surface energy measurements, electrical resistivity, contact potential difference, and thermal annealing indicates a correlation between some of the measured values and the interaction of the films with human blood platelets. Statistical analysis of platelet aggregation on the films using the Student's t-test indicated differences between platelet aggregation on the modified films compared to the as-deposited film at a p-value of < 0.05. (C) 2003 Elsevier Ltd. All rights reserved.

AB - We have investigated the effect of changes in microstructure, surface energy, surface charge condition and electronic conduction on the interaction of human platelets with silicon modified hydrogenated amorphous carbon films (a-C:H:Si or Si-DLC). Results based on Raman spectroscopy, Scanning electron microscopy, X-ray photo-electronspectroscopy, surface energy measurements, electrical resistivity, contact potential difference, and thermal annealing indicates a correlation between some of the measured values and the interaction of the films with human blood platelets. Statistical analysis of platelet aggregation on the films using the Student's t-test indicated differences between platelet aggregation on the modified films compared to the as-deposited film at a p-value of < 0.05. (C) 2003 Elsevier Ltd. All rights reserved.

KW - Si-DLC

KW - Raman spectroscopy

KW - haemocompatibility

KW - contact angle/surface energy

KW - work function/semi-conduction

KW - human platelet aggregation

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DO - 10.1016/S0142-9612(03)00494-0

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T2 - Biomaterials

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