Plasma levels of the immunomodulatory cytokine interleukin-10 during normal human pregnancy: a longitudinal study

VA Holmes, Julie Wallace, WS Gilmore, P McFaul, HD Alexander

    Research output: Contribution to journalArticle

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    Abstract

    Pregnancy is proposed to be a Th2 phenomenon, where Th2 cytokines inhibit Th1 responses to improve foetal Survival. The importance of interleukin-10 (IL-10), an immunomodulatory cytokine produced by Th2 cells, in the maintenance of normal pregnancy is becoming increasingly apparent. In a longitudinal case-control study, the physiological effect of pregnancy on plasma IL-10 was investigated. The plasma concentration of IL-10 was determined using an ELISA technique in 99 pregnant women sampled at 12. 20 and 35 weeks of gestation, 38 non-pregnant control subjects sampled in parallel and in a subgroup of women sampled at 3 days post-partum (it. pregnant 21, non-pregnant 21). Plasma IL-10 was significantly higher in pregnant women at 12, 20 and 35 weeks of gestation (p<0.05, p<0.01 and p<0.0001, respectively), and in mothers post-delivery (p<0.01) when compared to non-pregnant control subjects. Furthermore, there was no significant effect of gestational time on IL-10 concentration. Results from the current Study Suggest that elevated IL-10 is a physiological consequence of normal healthy pregnancy. These findings help clarify previous conflicting results and establish a range for plasma levels of IL-10 in normal healthy pregnancy. (C) 2003 Elsevier Science Ltd. All rights reserved.
    LanguageEnglish
    Pages265-269
    JournalCytokine
    Volume21
    Issue number6
    DOIs
    Publication statusPublished - Mar 2003

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    Interleukin-10
    Longitudinal Studies
    Cytokines
    Pregnancy
    Pregnant Women
    Pregnancy Maintenance
    Th2 Cells
    Case-Control Studies
    Enzyme-Linked Immunosorbent Assay
    Mothers
    Survival

    Cite this

    Holmes, VA ; Wallace, Julie ; Gilmore, WS ; McFaul, P ; Alexander, HD. / Plasma levels of the immunomodulatory cytokine interleukin-10 during normal human pregnancy: a longitudinal study. In: Cytokine. 2003 ; Vol. 21, No. 6. pp. 265-269.
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    abstract = "Pregnancy is proposed to be a Th2 phenomenon, where Th2 cytokines inhibit Th1 responses to improve foetal Survival. The importance of interleukin-10 (IL-10), an immunomodulatory cytokine produced by Th2 cells, in the maintenance of normal pregnancy is becoming increasingly apparent. In a longitudinal case-control study, the physiological effect of pregnancy on plasma IL-10 was investigated. The plasma concentration of IL-10 was determined using an ELISA technique in 99 pregnant women sampled at 12. 20 and 35 weeks of gestation, 38 non-pregnant control subjects sampled in parallel and in a subgroup of women sampled at 3 days post-partum (it. pregnant 21, non-pregnant 21). Plasma IL-10 was significantly higher in pregnant women at 12, 20 and 35 weeks of gestation (p<0.05, p<0.01 and p<0.0001, respectively), and in mothers post-delivery (p<0.01) when compared to non-pregnant control subjects. Furthermore, there was no significant effect of gestational time on IL-10 concentration. Results from the current Study Suggest that elevated IL-10 is a physiological consequence of normal healthy pregnancy. These findings help clarify previous conflicting results and establish a range for plasma levels of IL-10 in normal healthy pregnancy. (C) 2003 Elsevier Science Ltd. All rights reserved.",
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    Plasma levels of the immunomodulatory cytokine interleukin-10 during normal human pregnancy: a longitudinal study. / Holmes, VA; Wallace, Julie; Gilmore, WS; McFaul, P; Alexander, HD.

    In: Cytokine, Vol. 21, No. 6, 03.2003, p. 265-269.

    Research output: Contribution to journalArticle

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