Plants derived therapeutic strategies targeting chronic respiratory diseases: Chemical and immunological perspective

Parteek Prasher, Mousmee Sharma, Meenu Mehta, Keshav R. Paudel, Saurabh Satija, Dinesh K. Chellappan, Harish Dureja, Gaurav Gupta, Murtaza M. Tambuwala, Poonam Negi, Peter R. Wich, Nicole Hansbro, Philip M. Hansbro, Kamal Dua

Research output: Contribution to journalArticle

Abstract

The apparent predicament of the representative chemotherapy for managing respiratory distress calls for an obligatory deliberation for identifying the pharmaceuticals that effectively counter the contemporary intricacies associated with target disease. Multiple, complex regulatory pathways manifest chronic pulmonary disorders, which require chemotherapeutics that produce composite inhibitory effect. The cost effective natural product based molecules hold a high fervor to meet the prospects posed by current respiratory-distress therapy by sparing the tedious drug design and development archetypes, present a robust standing for the possible replacement of the fading practice of poly-pharmacology, and ensure the subversion of a potential disease relapse. This study summarizes the experimental evidences on natural products moieties and their components that illustrates therapeutic efficacy on respiratory disorders.
Original languageEnglish
Article number109125
Number of pages62
JournalChemico-Biological Interactions
Volume325
Early online date4 May 2020
DOIs
Publication statusPublished - 1 Jul 2020

Keywords

  • Alkaloids
  • COPD
  • Flavonoids
  • Natural products
  • Respiratory disorders

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    Prasher, P., Sharma, M., Mehta, M., Paudel, K. R., Satija, S., Chellappan, D. K., Dureja, H., Gupta, G., Tambuwala, M. M., Negi, P., Wich, P. R., Hansbro, N., Hansbro, P. M., & Dua, K. (2020). Plants derived therapeutic strategies targeting chronic respiratory diseases: Chemical and immunological perspective. Chemico-Biological Interactions, 325, [109125]. https://doi.org/10.1016/j.cbi.2020.109125