Plant based Gold Nanoparticles and Penetration through Blood Brain Barrier

V Dubey, R Owusu-Apenten, K Narain, Poonam Singh - Nee Nigam, A Semwal, S Tripathi

Research output: Contribution to journalReview articlepeer-review

Abstract

The blood brain barrier (BBB) is designated as one of the most vital shielding mechanism placed
in central nervous system (CNS) regulating brain microenvironment. Selectively allowing
only essential molecules like micro soluble lipids through capillary membrane while
obstructing the passage to toxins and pathogens. This mechanism is termed as essential for normal
well being of brain health; however, it also poses extreme challenges during disease
state hindering the adequate drug delivery to effected region. In recent years there have been
number of researches specifically exploring efficient drug delivery methods via penetration
through BBB such as structural modifications in prodrugs via using liposome, micelles,
dendrimers, carbon nanotubes, niosomes, beta cyclodextrin carriers etc or inducing osmotic
disruption in BBB etc. However, most of such strategies failed to provide substantial proof to
desired site specific activity across BBB. The current review here discusses plant mediated
Gold nanoparticles (AuNP’s) drug delivery system as a future transpiring non-invasive
system for brain related diseases and disorders as neuroprotective agents. The scope of
plants based AuNPs will be elaborated considering their recent advancement to
research activity and propensity to devise into therapeutics with ability to act across
BBB as targeted drug therapy. This could be a remarkable progress exploring green synthesis
protocols towards gold nanoparticles, reformulating equivalent novel strategies to in place conventional methods for cerebral diseases.

Original languageEnglish
Article numberIJPMR-495
Pages (from-to)11-17
Number of pages7
JournalInternational journal of Pharmaceutical and medicinal research
Volume8
Issue number3
Early online date30 Jun 2020
DOIs
Publication statusE-pub ahead of print - 30 Jun 2020

Keywords

  • Blood Brain Barriers AuNP’s Cerebral Diseases Neuroprotective

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