The blood brain barrier (BBB) is designated as one of the most vital shielding mechanism placed in central nervous system (CNS) regulating brain microenvironment. Selectively allowing only essential molecules like micro soluble lipids through capillary membrane while obstructing the passage to toxins and pathogens. This mechanism is termed as essential for normal well being of brain health; however, it also poses extreme challenges during disease state hindering the adequate drug delivery to effected region. In recent years there have been number of researches specifically exploring efficient drug delivery methods via penetration through BBB such as structural modifications in prodrugs via using liposome, micelles, dendrimers, carbon nanotubes, niosomes, beta cyclodextrin carriers etc or inducing osmotic disruption in BBB etc. However, most of such strategies failed to provide substantial proof to desired site specific activity across BBB. The current review here discusses plant mediated Gold nanoparticles (AuNP’s) drug delivery system as a future transpiring non-invasive system for brain related diseases and disorders as neuroprotective agents. The scope of plants based AuNPs will be elaborated considering their recent advancement to research activity and propensity to devise into therapeutics with ability to act across BBB as targeted drug therapy. This could be a remarkable progress exploring green synthesis protocols towards gold nanoparticles, reformulating equivalent novel strategies to in place conventional methods for cerebral diseases.
|Number of pages||7|
|Journal||International journal of Pharmaceutical and medicinal research|
|Early online date||30 Jun 2020|
|Publication status||Published online - 30 Jun 2020|
- Blood Brain Barriers AuNP’s Cerebral Diseases Neuroprotective