Plant based Gold Nanoparticles and Penetration through Blood Brain Barrier

Vaibhav Dubey, R Owusu-Apenten, K Narain, Poonam Singh - Nee Nigam, A Semwal, S Tripathi

Research output: Contribution to journalReview articlepeer-review

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Abstract

The blood brain barrier (BBB) is designated as one of the most vital shielding mechanism placed in central nervous system (CNS) regulating brain microenvironment. Selectively allowing only essential molecules like micro soluble lipids through capillary membrane while obstructing the passage to toxins and pathogens. This mechanism is termed as essential for normal well being of brain health; however, it also poses extreme challenges during disease state hindering the adequate drug delivery to effected region. In recent years there have been number of researches specifically exploring efficient drug delivery methods via penetration through BBB such as structural modifications in prodrugs via using liposome, micelles, dendrimers, carbon nanotubes, niosomes, beta cyclodextrin carriers etc or inducing osmotic disruption in BBB etc. However, most of such strategies failed to provide substantial proof to desired site specific activity across BBB. The current review here discusses plant mediated Gold nanoparticles (AuNP’s) drug delivery system as a future transpiring non-invasive system for brain related diseases and disorders as neuroprotective agents. The scope of plants based AuNPs will be elaborated considering their recent advancement to research activity and propensity to devise into therapeutics with ability to act across BBB as targeted drug therapy. This could be a remarkable progress exploring green synthesis protocols towards gold nanoparticles, reformulating equivalent novel strategies to in place conventional methods for cerebral diseases. 

Original languageEnglish
Article numberIJPMR-495
Pages (from-to)11-17
Number of pages7
JournalInternational journal of Pharmaceutical and medicinal research
Volume8
Issue number3
Early online date30 Jun 2020
DOIs
Publication statusPublished online - 30 Jun 2020

Keywords

  • Blood Brain Barriers AuNP’s Cerebral Diseases Neuroprotective

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