Pituitary adenylate cyclase-activating polypeptide and its receptors in amphibians

Laurent Yon; David Alexandre; Maité Montéro; Nicolas Chartrel; Lydie Jeandel; Mauro Vallarino; J. Michael Conlon; Sakae Kikuyama; Alain Fournier; Francisco Gracia-Navarro; Eric Roubos; Billy Chow; Akira Arimura; Youssef Anouar; Hubert Vaudry

doi:10.1002/jemt.1129

Pituitary adenylate cyclase-activating polypeptide and its receptors in amphibians

Laurent Yon, David Alexandre, Maité Montéro, Nicolas Chartrel, Lydie Jeandel, Mauro Vallarino, J. Michael Conlon, Sakae Kikuyama, Alain Fournier, Francisco Gracia-Navarro, Eric Roubos, Billy Chow, Akira Arimura, Youssef Anouar, Hubert Vaudry

School of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP), a novel peptide of the secretin/glucagon/vasoactive intestinal polypeptide superfamily, has been initially characterized in mammals in 1989 and, only 2 years later, its counterpart has been isolated in amphibians. A number of studies conducted in the frog Rana ridibunda have demonstrated that PACAP is widely distributed in the central nervous system (particularly in the hypothalamus and the median eminence) and in peripheral organs including the adrenal gland. The cDNAs encoding the PACAP precursor and 3 types of PACAP receptors have been cloned in amphibians and their distribution has been determined by in situ hybridization histochemistry. Ontogenetic studies have revealed that PACAP is expresssed early in the brain of tadpoles, soon after hatching. In the frog Rana ridibunda, PACAP exerts a large array of biological effects in the brain, pituitary, adrenal gland, and ovary, suggesting that, in amphibians as in mammals, PACAP may act as neurotrophic factor, a neurotransmitter and a neurohormone.

Original language	English
Pages (from-to)	137-157
Number of pages	21
Journal	Microscopy Research and Technique
Volume	54
Issue number	3
DOIs	https://doi.org/10.1002/jemt.1129
Publication status	Published (in print/issue) - 1 Aug 2001

Keywords

Adrenal gland
Central nervous system
Frog
PACAP
PACAP/VIP receptors
VIP

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10.1002/jemt.1129

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Yon, L., Alexandre, D., Montéro, M., Chartrel, N., Jeandel, L., Vallarino, M., Conlon, J. M., Kikuyama, S., Fournier, A., Gracia-Navarro, F., Roubos, E., Chow, B., Arimura, A., Anouar, Y., & Vaudry, H. (2001). Pituitary adenylate cyclase-activating polypeptide and its receptors in amphibians. Microscopy Research and Technique, 54(3), 137-157. https://doi.org/10.1002/jemt.1129

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title = "Pituitary adenylate cyclase-activating polypeptide and its receptors in amphibians",

abstract = "Pituitary adenylate cyclase-activating polypeptide (PACAP), a novel peptide of the secretin/glucagon/vasoactive intestinal polypeptide superfamily, has been initially characterized in mammals in 1989 and, only 2 years later, its counterpart has been isolated in amphibians. A number of studies conducted in the frog Rana ridibunda have demonstrated that PACAP is widely distributed in the central nervous system (particularly in the hypothalamus and the median eminence) and in peripheral organs including the adrenal gland. The cDNAs encoding the PACAP precursor and 3 types of PACAP receptors have been cloned in amphibians and their distribution has been determined by in situ hybridization histochemistry. Ontogenetic studies have revealed that PACAP is expresssed early in the brain of tadpoles, soon after hatching. In the frog Rana ridibunda, PACAP exerts a large array of biological effects in the brain, pituitary, adrenal gland, and ovary, suggesting that, in amphibians as in mammals, PACAP may act as neurotrophic factor, a neurotransmitter and a neurohormone.",

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Yon, L, Alexandre, D, Montéro, M, Chartrel, N, Jeandel, L, Vallarino, M, Conlon, JM, Kikuyama, S, Fournier, A, Gracia-Navarro, F, Roubos, E, Chow, B, Arimura, A, Anouar, Y & Vaudry, H 2001, 'Pituitary adenylate cyclase-activating polypeptide and its receptors in amphibians', Microscopy Research and Technique, vol. 54, no. 3, pp. 137-157. https://doi.org/10.1002/jemt.1129

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AU - Alexandre, David

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AU - Vallarino, Mauro

AU - Conlon, J. Michael

AU - Kikuyama, Sakae

AU - Fournier, Alain

AU - Gracia-Navarro, Francisco

AU - Roubos, Eric

AU - Chow, Billy

AU - Arimura, Akira

AU - Anouar, Youssef

AU - Vaudry, Hubert

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Pituitary adenylate cyclase-activating polypeptide and its receptors in amphibians

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Keywords

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