Pharmacologically Active Phytomolecules Isolated from Traditional Antidiabetic Plants and Their Therapeutic Role for the Management of Diabetes Mellitus

Prawej Ansari, S Akther, JMA Hannan, V Seidel, NJ Nujat, Yasser Abdel-Wahab

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Abstract

Diabetes mellitus is a chronic complication that affects people of all ages. The increased prevalence of diabetes worldwide has led to the development of several synthetic drugs to tackle this health problem. Such drugs, although effective as antihyperglycemic agents, are accompanied by various side effects, costly, and inaccessible to the majority of people living in underdeveloped countries. Medicinal plants have been used traditionally throughout the ages to treat various ailments due to their availability and safe nature. Medicinal plants are a rich source of phytochemicals that possess several health benefits. As diabetes continues to become prevalent, health care practitioners are considering plant-based medicines as a potential source of antidiabetic drugs due to their high potency and fewer side effects. To better understand the mechanism of action of medicinal plants, their active phytoconstituents are being isolated and investigated thoroughly. In this review article, we have focused on pharmacologically active phytomolecules isolated from medicinal
plants presenting antidiabetic activity and the role they play in the treatment and management of diabetes. These natural compounds may represent as good candidates for a novel therapeutic approach and/or effective and alternative therapies for diabetes.
Original languageEnglish
Article number4278
Pages (from-to)4278
JournalMolecules
Volume27
Issue number13
DOIs
Publication statusPublished - 3 Jul 2022

Bibliographical note

Funding Information:
We would like to extend our appreciation to Peter R Flatt, School of Biomedical Sciences, Ulster University, UK and Independent University, Bangladesh for his aid, guidance, and support in creating the innovative ideas.

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • diabetes
  • medicinal plants
  • pharmacology
  • phytoconstituents
  • traditional medicine

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