Abstract
Ganoderma, has been used for clinical applications for thousands of years as a highly-nutritious and significantly-effective medicinal herb. The active components and efficacy of Ganoderma are constantly being explored and supplemented every year. In recent years, more and more literature has reported the pharmacological effects of Ganoderma on anti-tumor, liver protection and immunity enhancement, especially on neuroprotection. Numerous research works on the neuroprotective effects of Ganoderma have been documented (e.g., modulation of neurogenesis, amelioration of Alzheimer's disease, therapeutic effect on epilepsy, the protective effect on neural cells in stroke injury, etc.) thus it has drawn increasing attention. However, an integrated and comprehensive review of recent research findings has not been detailed in any great depth. Therefore, the purpose of this review is to summarize and elucidate recent progress of neuroprotective effects of natural Ganoderma and its extracts.
| Original language | English |
|---|---|
| Pages (from-to) | 1160-1178 |
| Number of pages | 19 |
| Journal | International Journal of Biological Macromolecules |
| Volume | 121 |
| Early online date | 18 Oct 2018 |
| DOIs | |
| Publication status | Published (in print/issue) - 1 Jan 2019 |
Funding
This work was financially supported by the National Nature Science Foundation of China (No. 81771960 ), the Fundamental Research Funds for the Central Universities ( 2017QNA5017 ) and Key Technologies R&D Program of Zhejiang Province ( 2015C02035 ).
Keywords
- Ganoderma
- Neurological diseases
- Traditional Chinese medicine
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