Pharmaceutical and biomaterial engineering via electrohydrodynamic atomization technologies

Prina Mehta, Rita Haj-Ahmad, Manoochehr Rasekh, Muhammad S. Arshad, Ashleigh Smith, Susanna M. van der Merwe, Xiang Li, Ming Wei Chang, Zeeshan Ahmad

Research output: Contribution to journalReview article

64 Citations (Scopus)

Abstract

Complex micro- and nano-structures enable crucial developments in the healthcare remit (e.g., pharmaceutical and biomaterial sciences). In recent times, several technologies have been developed and explored to address key healthcare challenges (e.g., advanced chemotherapy, biomedical diagnostics and tissue regeneration). Electrohydrodynamic atomization (EHDA) technologies are rapidly emerging as promising candidates to address these issues. The fundamental principle driving EHDA engineering relates to the action of an electric force (field) on flowing conducting medium (formulation) giving rise to a stable Taylor cone. Through careful optimization of process parameters, material properties and selection, nozzle and needle design, and collection substrate method, complex active micro- and nano-structures are engineered. This short review focuses on key selected recent and established advances in the field of pharmaceutical and biomaterial applications.

Original languageEnglish
Pages (from-to)157-165
Number of pages9
JournalDrug Discovery Today
Volume22
Issue number1
Early online date28 Sep 2016
DOIs
Publication statusPublished - 1 Jan 2017

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    Mehta, P., Haj-Ahmad, R., Rasekh, M., Arshad, M. S., Smith, A., van der Merwe, S. M., Li, X., Chang, M. W., & Ahmad, Z. (2017). Pharmaceutical and biomaterial engineering via electrohydrodynamic atomization technologies. Drug Discovery Today, 22(1), 157-165. https://doi.org/10.1016/j.drudis.2016.09.021