PEG Functionalized Gold Nanoparticle Loaded PLGA Films for Drug Delivery

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A novel composite of poly (ethylene glycol) (PEG) functionalized gold nanoparticles (AuNP-PEG) dispersed within Poly (lactic-go-glycolic) (PLGA) films, were prepared to demonstrate the concept of a combined targeted and sustained implant material. This technology offers the promise of improved therapies for difficult to treat tumors such as Gliomas. Gold nanoparticles (AuNPs) synthesized via a modified Turkevich method, were functionalized with thiol terminated polyethylene glycol (PEG), washed using centrifugation, dried, re-suspended in a solution of PLGA in dichloromethane and finally vacuum dried to produce the solvent cast films. The degradation and nanoparticle release profile of these films were studied by immersion in PBS media at 37 °C over periods of up-to 58 days. Thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) was conducted. The release of the AuNPs-PEG nanoparticles during degradation was studied using inductively coupled plasma mass spectroscopy (ICP-MS). It was observed that the AuNP-PEG nanoparticles were individually dispersed within the PLGA and that their addition extended the degradation time of the PLGA film, but did not appear to alter the nature of degradation. The nanoparticle release from the composite films displayed an approximately zero-order release profile.
LanguageEnglish
Pages83-94
JournalJournal of Nano Research
Volume27
DOIs
Publication statusPublished - 1 Mar 2014

Fingerprint

Drug delivery
Gold
Nanoparticles
Degradation
Centrifugation
Methylene Chloride
Inductively coupled plasma
Composite films
Sulfhydryl Compounds
Polyethylene glycols
Thermogravimetric analysis
polylactic acid-polyglycolic acid copolymer
Tumors
Differential scanning calorimetry
Spectroscopy
Vacuum
Scanning electron microscopy
Composite materials

Keywords

  • Nanomedicine
  • gold nanoparticles

Cite this

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title = "PEG Functionalized Gold Nanoparticle Loaded PLGA Films for Drug Delivery",
abstract = "A novel composite of poly (ethylene glycol) (PEG) functionalized gold nanoparticles (AuNP-PEG) dispersed within Poly (lactic-go-glycolic) (PLGA) films, were prepared to demonstrate the concept of a combined targeted and sustained implant material. This technology offers the promise of improved therapies for difficult to treat tumors such as Gliomas. Gold nanoparticles (AuNPs) synthesized via a modified Turkevich method, were functionalized with thiol terminated polyethylene glycol (PEG), washed using centrifugation, dried, re-suspended in a solution of PLGA in dichloromethane and finally vacuum dried to produce the solvent cast films. The degradation and nanoparticle release profile of these films were studied by immersion in PBS media at 37 °C over periods of up-to 58 days. Thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) was conducted. The release of the AuNPs-PEG nanoparticles during degradation was studied using inductively coupled plasma mass spectroscopy (ICP-MS). It was observed that the AuNP-PEG nanoparticles were individually dispersed within the PLGA and that their addition extended the degradation time of the PLGA film, but did not appear to alter the nature of degradation. The nanoparticle release from the composite films displayed an approximately zero-order release profile.",
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PEG Functionalized Gold Nanoparticle Loaded PLGA Films for Drug Delivery. / Dixon, D; Meenan, BJ.

In: Journal of Nano Research, Vol. 27, 01.03.2014, p. 83-94.

Research output: Contribution to journalArticle

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AB - A novel composite of poly (ethylene glycol) (PEG) functionalized gold nanoparticles (AuNP-PEG) dispersed within Poly (lactic-go-glycolic) (PLGA) films, were prepared to demonstrate the concept of a combined targeted and sustained implant material. This technology offers the promise of improved therapies for difficult to treat tumors such as Gliomas. Gold nanoparticles (AuNPs) synthesized via a modified Turkevich method, were functionalized with thiol terminated polyethylene glycol (PEG), washed using centrifugation, dried, re-suspended in a solution of PLGA in dichloromethane and finally vacuum dried to produce the solvent cast films. The degradation and nanoparticle release profile of these films were studied by immersion in PBS media at 37 °C over periods of up-to 58 days. Thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) was conducted. The release of the AuNPs-PEG nanoparticles during degradation was studied using inductively coupled plasma mass spectroscopy (ICP-MS). It was observed that the AuNP-PEG nanoparticles were individually dispersed within the PLGA and that their addition extended the degradation time of the PLGA film, but did not appear to alter the nature of degradation. The nanoparticle release from the composite films displayed an approximately zero-order release profile.

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