Patient-Specific Modelling and Parameter Optimisation to Simulate Dilated Cardiomyopathy in Children

Selim Bozkurt, Waleed Paracha, Kaushiki Bakaya, Silvia Schievano

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
29 Downloads (Pure)


Lumped parameter modelling has been widely used to simulate cardiac function and physiological scenarios in cardiovascular research. Whereas several patient-specific lumped parameter models have been reported for adults, there is a limited number of studies aiming to simulate cardiac function in children. The aim of this study is to simulate patient-specific cardiovascular dynamics in children diagnosed with dilated cardiomyopathy, using a lumped parameter model.
Patient data including age, gender, heart rate, left and right ventricular end-systolic and end-diastolic volumes, cardiac output, systolic and diastolic aortic pressures were collected from 3 patients at Great Ormond Street Hospital for Children, London, UK. Ventricular geometrical data were additionally retrieved from cardiovascular magnetic resonance images. 23 parameters in the lumped parameter model were optimised to simulate systolic and diastolic pressures, end-systolic and end-diastolic volumes, cardiac output and left and right ventricular diameters in the patients using a direct search optimisation method.
Difference between the haemodynamic parameters in the optimised cardiovascular system models and clinical data was less than 10%.
The simulation results show the potential of patient-specific lumped parameter modelling to simulate clinical cases. Modelling patient specific cardiac function and blood flow in the paediatric patients would allow us to evaluate a variety of physiological scenarios and treatment options.
Original languageEnglish
Pages (from-to)712-724
Number of pages13
JournalCardiovascular Engineering and Technology
Issue number5
Early online date22 Feb 2022
Publication statusPublished online - 22 Feb 2022

Bibliographical note

Publisher Copyright:
© 2022, The Author(s).

Funding Information:
The authors received no specific funding for this work. The authors declare no conflict of interest. Data was analysed in accordance with the guidelines laid out in the Declaration of Helsinki. Ethical approval was obtained for the use of image data for research purposes (UK REC 06/Q0508/124). All parents/guardians gave written informed consent to participate in this study.

Publisher Copyright:
© 2022, The Author(s).


  • Lumped parameter model
  • Patient-specific cardiac function
  • Dilated cardiomyopathy
  • Paediatrics


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