Patient-Specific Modelling and Parameter Optimisation to Simulate Dilated Cardiomyopathy in Children

Selim Bozkurt, Waleed Paracha, Kaushiki Bakaya, Silvia Schievano

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Abstract

Purpose
Lumped parameter modelling has been widely used to simulate cardiac function and physiological scenarios in cardiovascular research. Whereas several patient-specific lumped parameter models have been reported for adults, there is a limited number of studies aiming to simulate cardiac function in children. The aim of this study is to simulate patient-specific cardiovascular dynamics in children diagnosed with dilated cardiomyopathy, using a lumped parameter model.
Methods
Patient data including age, gender, heart rate, left and right ventricular end-systolic and end-diastolic volumes, cardiac output, systolic and diastolic aortic pressures were collected from 3 patients at Great Ormond Street Hospital for Children, London, UK. Ventricular geometrical data were additionally retrieved from cardiovascular magnetic resonance images. 23 parameters in the lumped parameter model were optimised to simulate systolic and diastolic pressures, end-systolic and end-diastolic volumes, cardiac output and left and right ventricular diameters in the patients using a direct search optimisation method.
Results
Difference between the haemodynamic parameters in the optimised cardiovascular system models and clinical data was less than 10%.
Conclusion
The simulation results show the potential of patient-specific lumped parameter modelling to simulate clinical cases. Modelling patient specific cardiac function and blood flow in the paediatric patients would allow us to evaluate a variety of physiological scenarios and treatment options.
Original languageEnglish
JournalCardiovascular Engineering and Technology
Early online date22 Feb 2022
DOIs
Publication statusE-pub ahead of print - 22 Feb 2022

Bibliographical note

Publisher Copyright:
© 2022, The Author(s).

Keywords

  • Lumped parameter model
  • Patient-specific cardiac function
  • Dilated cardiomyopathy
  • Paediatrics

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