Parenteral antioxidant treatment preserves temporal discrimination following intrahippocampal aggregated A beta((1-42)) injections

DG McDaid, Eun-Mee Kim, RE Reid, Julian Leslie, J Cleary, E O'Hare

Research output: Contribution to journalArticle

Abstract

There is evidence that oxidative stress may play a role in the neuropathology of Alzheimer's disease (AD). This study used an aggregated beta-amyloid (A beta) injection model of AD in the rat, and a recycling conjunctive schedule of food reinforcement to examine the effects of bilateral intrahippocampal injections of aggregated A beta((1-42)) (5.0 mu l/side) on temporal discrimination, and the efficacy of the antioxidant alpha-tocopherol (150 mg/kg daily p.o.) in alleviating these effects. The results indicated that bilateral intrahippocampal injections of aggregated A beta((1-42)) detrimentally affected temporal discrimination from five-day block 31-35 post-injections until the end of the study (90 days post-injections). Daily treatment with alpha-tocopherol improved temporal discrimination under the recycling conjunctive schedule following aggregated A beta((1-42)) injections from the five-day block 61-65 days until the end of the study.
LanguageEnglish
Pages237-242
JournalBehavioural Pharmacology
Volume16
Issue number4
Publication statusPublished - Jul 2005

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Antioxidants
Injections
Recycling
alpha-Tocopherol
Alzheimer Disease
Therapeutics
Reinforcement Schedule
Amyloid
Discrimination (Psychology)
amyloid beta-protein (1-42)
Appointments and Schedules
Oxidative Stress
Food

Cite this

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title = "Parenteral antioxidant treatment preserves temporal discrimination following intrahippocampal aggregated A beta((1-42)) injections",
abstract = "There is evidence that oxidative stress may play a role in the neuropathology of Alzheimer's disease (AD). This study used an aggregated beta-amyloid (A beta) injection model of AD in the rat, and a recycling conjunctive schedule of food reinforcement to examine the effects of bilateral intrahippocampal injections of aggregated A beta((1-42)) (5.0 mu l/side) on temporal discrimination, and the efficacy of the antioxidant alpha-tocopherol (150 mg/kg daily p.o.) in alleviating these effects. The results indicated that bilateral intrahippocampal injections of aggregated A beta((1-42)) detrimentally affected temporal discrimination from five-day block 31-35 post-injections until the end of the study (90 days post-injections). Daily treatment with alpha-tocopherol improved temporal discrimination under the recycling conjunctive schedule following aggregated A beta((1-42)) injections from the five-day block 61-65 days until the end of the study.",
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Parenteral antioxidant treatment preserves temporal discrimination following intrahippocampal aggregated A beta((1-42)) injections. / McDaid, DG; Kim, Eun-Mee; Reid, RE; Leslie, Julian; Cleary, J; O'Hare, E.

In: Behavioural Pharmacology, Vol. 16, No. 4, 07.2005, p. 237-242.

Research output: Contribution to journalArticle

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AU - McDaid, DG

AU - Kim, Eun-Mee

AU - Reid, RE

AU - Leslie, Julian

AU - Cleary, J

AU - O'Hare, E

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AB - There is evidence that oxidative stress may play a role in the neuropathology of Alzheimer's disease (AD). This study used an aggregated beta-amyloid (A beta) injection model of AD in the rat, and a recycling conjunctive schedule of food reinforcement to examine the effects of bilateral intrahippocampal injections of aggregated A beta((1-42)) (5.0 mu l/side) on temporal discrimination, and the efficacy of the antioxidant alpha-tocopherol (150 mg/kg daily p.o.) in alleviating these effects. The results indicated that bilateral intrahippocampal injections of aggregated A beta((1-42)) detrimentally affected temporal discrimination from five-day block 31-35 post-injections until the end of the study (90 days post-injections). Daily treatment with alpha-tocopherol improved temporal discrimination under the recycling conjunctive schedule following aggregated A beta((1-42)) injections from the five-day block 61-65 days until the end of the study.

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