Oxygen enhanced MRI biomarkers of lung function in interstitial lung disease

Marta Tibiletti; Josephine Naish; Matthew J Heaton; John Waterton; Paul Hughes; James A Eaden; Sarah Skeoch; Nazia Chaudhuri; Ian Bruce; Stephen M. Bianchi; Jim Wild; Geoff Jm Parker

doi:10.1183/13993003.congress-2020.4330

Oxygen enhanced MRI biomarkers of lung function in interstitial lung disease

Marta Tibiletti
, Josephine Naish
, Matthew J Heaton
, John Waterton
, Paul Hughes
, James A Eaden
, Sarah Skeoch
, Nazia Chaudhuri
, Ian Bruce
, Stephen M. Bianchi
, Jim Wild
, Geoff Jm Parker

Research output: Contribution to journal › Conference article › peer-review

Abstract

Introduction: Novel biomarkers are needed to improve assessment of ILD. Oxygen enhanced MRI (OE-MRI) monitors regional O2 delivery from changes in the MRI relaxation time T1 in response to hyperoxia. We present OE-MRI biomarkers in different ILD phenotypes (IPF, DI-ILD, CTD-ILD, HSP) acquired in a prospective observational study and compare them with lung function tests under standard clinical care.

Methods: Patients recruited and scans analysed to date are summarised in fig 1. The OE MR parameters considered were: baseline T1, change in delta pO2 (ΔpO2), O2 wash-in time and ventilated volume fraction. Biomarker values at each visit and the change between visits were compared with lung function tests (FVC%, FEV1%, Tlco%, KCO%) using Pearson correlation (no correction for multiple comparisons).

Results: In the IPF subgroup, T1 correlated with Tlco% and KCO% (r=-0.43, p=0.027 and r=-0.43, p=0.028). Changes between visits in ΔpO2 and in KCO%(r = 0.86, p=0.003) were also correlated. No significant correlations were found in other phenotypes.

Conclusions: In IPF, change between visits in ΔpO2 correlates with the change in KCO%, but not in the other ILD subtypes.

Original language	English
Article number	4330
Journal	European Respiratory Journal
Volume	56
Issue number	Suppl 64
DOIs	https://doi.org/10.1183/13993003.congress-2020.4330
Publication status	Published online - 28 Oct 2020

Bibliographical note

This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

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Tibiletti, M., Naish, J., Heaton, M. J., Waterton, J., Hughes, P., Eaden, J. A., Skeoch, S., Chaudhuri, N., Bruce, I., Bianchi, S. M., Wild, J., & Parker, G. J. (2020). Oxygen enhanced MRI biomarkers of lung function in interstitial lung disease. European Respiratory Journal, 56(Suppl 64), Article 4330. Advance online publication. https://doi.org/10.1183/13993003.congress-2020.4330

@article{8d456c45521a43c0be49d8d5b6e5f42c,

title = "Oxygen enhanced MRI biomarkers of lung function in interstitial lung disease",

abstract = "Introduction: Novel biomarkers are needed to improve assessment of ILD. Oxygen enhanced MRI (OE-MRI) monitors regional O2 delivery from changes in the MRI relaxation time T1 in response to hyperoxia. We present OE-MRI biomarkers in different ILD phenotypes (IPF, DI-ILD, CTD-ILD, HSP) acquired in a prospective observational study and compare them with lung function tests under standard clinical care. Methods: Patients recruited and scans analysed to date are summarised in fig 1. The OE MR parameters considered were: baseline T1, change in delta pO2 (ΔpO2), O2 wash-in time and ventilated volume fraction. Biomarker values at each visit and the change between visits were compared with lung function tests (FVC\%, FEV1\%, Tlco\%, KCO\%) using Pearson correlation (no correction for multiple comparisons). Results: In the IPF subgroup, T1 correlated with Tlco\% and KCO\% (r=-0.43, p=0.027 and r=-0.43, p=0.028). Changes between visits in ΔpO2 and in KCO\%(r = 0.86, p=0.003) were also correlated. No significant correlations were found in other phenotypes. Conclusions: In IPF, change between visits in ΔpO2 correlates with the change in KCO\%, but not in the other ILD subtypes.",

author = "Marta Tibiletti and Josephine Naish and Heaton, \{Matthew J\} and John Waterton and Paul Hughes and Eaden, \{James A\} and Sarah Skeoch and Nazia Chaudhuri and Ian Bruce and Bianchi, \{Stephen M.\} and Jim Wild and Parker, \{Geoff Jm\}",

note = "This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the {"}pre COVID-19{"} era”. This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).",

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doi = "10.1183/13993003.congress-2020.4330",

language = "English",

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T1 - Oxygen enhanced MRI biomarkers of lung function in interstitial lung disease

AU - Tibiletti, Marta

AU - Naish, Josephine

AU - Heaton, Matthew J

AU - Waterton, John

AU - Hughes, Paul

AU - Eaden, James A

AU - Skeoch, Sarah

AU - Chaudhuri, Nazia

AU - Bruce, Ian

AU - Bianchi, Stephen M.

AU - Wild, Jim

AU - Parker, Geoff Jm

N1 - This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”. This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

PY - 2020/10/28

Y1 - 2020/10/28

N2 - Introduction: Novel biomarkers are needed to improve assessment of ILD. Oxygen enhanced MRI (OE-MRI) monitors regional O2 delivery from changes in the MRI relaxation time T1 in response to hyperoxia. We present OE-MRI biomarkers in different ILD phenotypes (IPF, DI-ILD, CTD-ILD, HSP) acquired in a prospective observational study and compare them with lung function tests under standard clinical care. Methods: Patients recruited and scans analysed to date are summarised in fig 1. The OE MR parameters considered were: baseline T1, change in delta pO2 (ΔpO2), O2 wash-in time and ventilated volume fraction. Biomarker values at each visit and the change between visits were compared with lung function tests (FVC%, FEV1%, Tlco%, KCO%) using Pearson correlation (no correction for multiple comparisons). Results: In the IPF subgroup, T1 correlated with Tlco% and KCO% (r=-0.43, p=0.027 and r=-0.43, p=0.028). Changes between visits in ΔpO2 and in KCO%(r = 0.86, p=0.003) were also correlated. No significant correlations were found in other phenotypes. Conclusions: In IPF, change between visits in ΔpO2 correlates with the change in KCO%, but not in the other ILD subtypes.

AB - Introduction: Novel biomarkers are needed to improve assessment of ILD. Oxygen enhanced MRI (OE-MRI) monitors regional O2 delivery from changes in the MRI relaxation time T1 in response to hyperoxia. We present OE-MRI biomarkers in different ILD phenotypes (IPF, DI-ILD, CTD-ILD, HSP) acquired in a prospective observational study and compare them with lung function tests under standard clinical care. Methods: Patients recruited and scans analysed to date are summarised in fig 1. The OE MR parameters considered were: baseline T1, change in delta pO2 (ΔpO2), O2 wash-in time and ventilated volume fraction. Biomarker values at each visit and the change between visits were compared with lung function tests (FVC%, FEV1%, Tlco%, KCO%) using Pearson correlation (no correction for multiple comparisons). Results: In the IPF subgroup, T1 correlated with Tlco% and KCO% (r=-0.43, p=0.027 and r=-0.43, p=0.028). Changes between visits in ΔpO2 and in KCO%(r = 0.86, p=0.003) were also correlated. No significant correlations were found in other phenotypes. Conclusions: In IPF, change between visits in ΔpO2 correlates with the change in KCO%, but not in the other ILD subtypes.

U2 - 10.1183/13993003.congress-2020.4330

DO - 10.1183/13993003.congress-2020.4330

M3 - Conference article

SN - 0903-1936

VL - 56

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - Suppl 64

M1 - 4330

ER -

Oxygen enhanced MRI biomarkers of lung function in interstitial lung disease

Abstract

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