Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours

J Callan, C McEwan, J Owen, E Stride, Colin Fowley, Heather Nesbitt, D Cochrane, CC Coussios, M Borden, N Nomikou, AP McHale

Research output: Contribution to journalArticle

Abstract

Tumour hypoxia represents a major challenge in the effective treatment of solid cancerous tumours using conventional approaches. As oxygen is a key substrate for Photo-/Sono-dynamic Therapy (PDT/SDT), hypoxia is also problematic for the treatment of solid tumours using these techniques. The ability to deliver oxygen to the vicinity of the tumour increases its local partial pressure improving the possibility of ROS generation in PDT/SDT. In this manuscript, we investigate the use of oxygen-loaded, lipid-stabilised microbubbles(MBs),decorated with a Rose Bengal sensitiser, for SDT-based treatment of a pancreatic cancer model (BxPc-3) in vitro and in vivo. We directly compare the effectiveness of the oxygen-loaded MBs with sulphur hexafluoride (SF6)-loaded MBs and reveal a significant improvement in therapeutic efficacy. The combination of oxygen-carrying, ultrasound-responsive MBs, with an ultrasound-responsive therapeutic sensitiser, offers the possibility of delivering and activating the MB-sensitiser conjugate at the tumour site in a non-invasive manner, providing enhanced sonodynamic activation at that site.
LanguageEnglish
Pages51-56
JournalJournal of Controlled Release
Volume203
Publication statusAccepted/In press - 3 Feb 2015

Fingerprint

Microbubbles
Oxygen
Neoplasms
Sulfur Hexafluoride
Therapeutics
Rose Bengal
Partial Pressure
Pancreatic Neoplasms
Lipids

Keywords

  • Hypoxia
  • Microbubbles
  • SDT
  • Rose Bengal
  • Cancer
  • Pancreatic

Cite this

Callan, J ; McEwan, C ; Owen, J ; Stride, E ; Fowley, Colin ; Nesbitt, Heather ; Cochrane, D ; Coussios, CC ; Borden, M ; Nomikou, N ; McHale, AP. / Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours. In: Journal of Controlled Release. 2015 ; Vol. 203. pp. 51-56.
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abstract = "Tumour hypoxia represents a major challenge in the effective treatment of solid cancerous tumours using conventional approaches. As oxygen is a key substrate for Photo-/Sono-dynamic Therapy (PDT/SDT), hypoxia is also problematic for the treatment of solid tumours using these techniques. The ability to deliver oxygen to the vicinity of the tumour increases its local partial pressure improving the possibility of ROS generation in PDT/SDT. In this manuscript, we investigate the use of oxygen-loaded, lipid-stabilised microbubbles(MBs),decorated with a Rose Bengal sensitiser, for SDT-based treatment of a pancreatic cancer model (BxPc-3) in vitro and in vivo. We directly compare the effectiveness of the oxygen-loaded MBs with sulphur hexafluoride (SF6)-loaded MBs and reveal a significant improvement in therapeutic efficacy. The combination of oxygen-carrying, ultrasound-responsive MBs, with an ultrasound-responsive therapeutic sensitiser, offers the possibility of delivering and activating the MB-sensitiser conjugate at the tumour site in a non-invasive manner, providing enhanced sonodynamic activation at that site.",
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Callan, J, McEwan, C, Owen, J, Stride, E, Fowley, C, Nesbitt, H, Cochrane, D, Coussios, CC, Borden, M, Nomikou, N & McHale, AP 2015, 'Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours', Journal of Controlled Release, vol. 203, pp. 51-56.

Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours. / Callan, J; McEwan, C; Owen, J; Stride, E; Fowley, Colin; Nesbitt, Heather; Cochrane, D; Coussios, CC; Borden, M; Nomikou, N; McHale, AP.

In: Journal of Controlled Release, Vol. 203, 03.02.2015, p. 51-56.

Research output: Contribution to journalArticle

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T1 - Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours

AU - Callan, J

AU - McEwan, C

AU - Owen, J

AU - Stride, E

AU - Fowley, Colin

AU - Nesbitt, Heather

AU - Cochrane, D

AU - Coussios, CC

AU - Borden, M

AU - Nomikou, N

AU - McHale, AP

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Y1 - 2015/2/3

N2 - Tumour hypoxia represents a major challenge in the effective treatment of solid cancerous tumours using conventional approaches. As oxygen is a key substrate for Photo-/Sono-dynamic Therapy (PDT/SDT), hypoxia is also problematic for the treatment of solid tumours using these techniques. The ability to deliver oxygen to the vicinity of the tumour increases its local partial pressure improving the possibility of ROS generation in PDT/SDT. In this manuscript, we investigate the use of oxygen-loaded, lipid-stabilised microbubbles(MBs),decorated with a Rose Bengal sensitiser, for SDT-based treatment of a pancreatic cancer model (BxPc-3) in vitro and in vivo. We directly compare the effectiveness of the oxygen-loaded MBs with sulphur hexafluoride (SF6)-loaded MBs and reveal a significant improvement in therapeutic efficacy. The combination of oxygen-carrying, ultrasound-responsive MBs, with an ultrasound-responsive therapeutic sensitiser, offers the possibility of delivering and activating the MB-sensitiser conjugate at the tumour site in a non-invasive manner, providing enhanced sonodynamic activation at that site.

AB - Tumour hypoxia represents a major challenge in the effective treatment of solid cancerous tumours using conventional approaches. As oxygen is a key substrate for Photo-/Sono-dynamic Therapy (PDT/SDT), hypoxia is also problematic for the treatment of solid tumours using these techniques. The ability to deliver oxygen to the vicinity of the tumour increases its local partial pressure improving the possibility of ROS generation in PDT/SDT. In this manuscript, we investigate the use of oxygen-loaded, lipid-stabilised microbubbles(MBs),decorated with a Rose Bengal sensitiser, for SDT-based treatment of a pancreatic cancer model (BxPc-3) in vitro and in vivo. We directly compare the effectiveness of the oxygen-loaded MBs with sulphur hexafluoride (SF6)-loaded MBs and reveal a significant improvement in therapeutic efficacy. The combination of oxygen-carrying, ultrasound-responsive MBs, with an ultrasound-responsive therapeutic sensitiser, offers the possibility of delivering and activating the MB-sensitiser conjugate at the tumour site in a non-invasive manner, providing enhanced sonodynamic activation at that site.

KW - Hypoxia

KW - Microbubbles

KW - SDT

KW - Rose Bengal

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KW - Pancreatic

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