Oxidative stress and immunological complexities in multidrug-resistant tuberculosis

Ridhima Wadhwa, Nikita Sehgal, G. Naresh, Taru Aggarwal, Saurabh Satija, Meenu Mehta, Gaurav Gupta, Dinesh K. Chellappan, Murtaza M. Tambuwala, Brain Oliver, Trudi Collet, Pawan K. Maurya, Philip M. Hansbro, Kamal Dua

    Research output: Chapter in Book/Report/Conference proceedingChapter

    1 Citation (Scopus)

    Abstract

    Mycobacterium tuberculosis (Mtb), the causitive agent of Tuberculosis (TB) is the leading cause of infection. The infection is caused by aerosols and infects the alveolar macrophage. The lungs counteract against the infection by the antioxidant system in response to the oxidative stress (OS) caused. Mycobacteriumstimulates the lung macrophage to produce reactive oxygen species (ROS). Furthermore, the treatment involves long term multiple drug regimens resulting in poor patient compliance leading to multidrug resistance (MDR-TB). The different first-line and second-line antibiotics are administered in an inactive form which gets converted into the active form by the OS response system of the host and the Mtb. Mtb alters the redox balance via mycolic acid, NADH/NAD+ ratio, and antioxidant enzymes in response to stress. In the following chapter, we have discussed the role of oxidative stress in the host and the pathogen along with the immunological complexities and the genetic modifications resulting in multidrug-resistant tuberculosis. It also discusses the different strategies to target the Mtb infection.

    Original languageEnglish
    Title of host publicationRole of Oxidative Stress in Pathophysiology of Diseases
    PublisherSpringer Singapore
    Pages107-124
    Number of pages18
    ISBN (Electronic)9789811515682
    ISBN (Print)9789811515675
    DOIs
    Publication statusPublished - 1 Jan 2020

    Keywords

    • Drug-susceptible tuberculosis
    • Multidrug-resistant tuberculosis
    • Mycobacterium tuberculosis
    • Oxidative stress

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