TY - CHAP
T1 - Oxidative stress and immunological complexities in multidrug-resistant tuberculosis
AU - Wadhwa, Ridhima
AU - Sehgal, Nikita
AU - Naresh, G.
AU - Aggarwal, Taru
AU - Satija, Saurabh
AU - Mehta, Meenu
AU - Gupta, Gaurav
AU - Chellappan, Dinesh K.
AU - Tambuwala, Murtaza M.
AU - Oliver, Brain
AU - Collet, Trudi
AU - Maurya, Pawan K.
AU - Hansbro, Philip M.
AU - Dua, Kamal
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Mycobacterium tuberculosis (Mtb), the causitive agent of Tuberculosis (TB) is the leading cause of infection. The infection is caused by aerosols and infects the alveolar macrophage. The lungs counteract against the infection by the antioxidant system in response to the oxidative stress (OS) caused. Mycobacteriumstimulates the lung macrophage to produce reactive oxygen species (ROS). Furthermore, the treatment involves long term multiple drug regimens resulting in poor patient compliance leading to multidrug resistance (MDR-TB). The different first-line and second-line antibiotics are administered in an inactive form which gets converted into the active form by the OS response system of the host and the Mtb. Mtb alters the redox balance via mycolic acid, NADH/NAD+ ratio, and antioxidant enzymes in response to stress. In the following chapter, we have discussed the role of oxidative stress in the host and the pathogen along with the immunological complexities and the genetic modifications resulting in multidrug-resistant tuberculosis. It also discusses the different strategies to target the Mtb infection.
AB - Mycobacterium tuberculosis (Mtb), the causitive agent of Tuberculosis (TB) is the leading cause of infection. The infection is caused by aerosols and infects the alveolar macrophage. The lungs counteract against the infection by the antioxidant system in response to the oxidative stress (OS) caused. Mycobacteriumstimulates the lung macrophage to produce reactive oxygen species (ROS). Furthermore, the treatment involves long term multiple drug regimens resulting in poor patient compliance leading to multidrug resistance (MDR-TB). The different first-line and second-line antibiotics are administered in an inactive form which gets converted into the active form by the OS response system of the host and the Mtb. Mtb alters the redox balance via mycolic acid, NADH/NAD+ ratio, and antioxidant enzymes in response to stress. In the following chapter, we have discussed the role of oxidative stress in the host and the pathogen along with the immunological complexities and the genetic modifications resulting in multidrug-resistant tuberculosis. It also discusses the different strategies to target the Mtb infection.
KW - Drug-susceptible tuberculosis
KW - Multidrug-resistant tuberculosis
KW - Mycobacterium tuberculosis
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85089633382&partnerID=8YFLogxK
U2 - 10.1007/978-981-15-1568-2_7
DO - 10.1007/978-981-15-1568-2_7
M3 - Chapter
AN - SCOPUS:85089633382
SN - 9789811515675
SP - 107
EP - 124
BT - Role of Oxidative Stress in Pathophysiology of Diseases
PB - Springer Singapore
ER -