Overview of therapeutic targets in management of dementia

Rohit Malik, Sunishtha Kalra, Saurabh Bhatia, Ahmed Al Harrasi, Govind Singh, Syam Mohan, Hafiz A Makeen, Mohammed Albratty, Abdulkarim Meraya, Bojlul Bahar, Murtaza M Tambuwala

Research output: Contribution to journalReview articlepeer-review

Abstract

Dementia is defined as a gradual cognitive impairment that interferes with everyday tasks, and is a leading cause of dependency, disability, and mortality. According to the current scenario, millions of individuals worldwide have dementia. This review provides with an overview of dementia before moving on to its subtypes (neurodegenerative and non-neurodegenerative) and pathophysiology. It also discusses the incidence and severity of dementia, focusing on Alzheimer's disease with its different hypotheses such as Aβ cascade hypothesis, Tau hypothesis, inflammatory hypothesis, cholinergic and oxidative stress hypothesis. Alzheimer's disease is the most common type and a progressive neurodegenerative illness distinct by neuronal loss and resulting cognitive impairment, leading to dementia. Alzheimer's disease (AD) is considered the most familiar neurodegenerative dementias that affect mostly older population. There are still no disease-modifying therapies available for any dementias at this time, but there are various methods for lowering the risk to dementia patients by using suitable diagnostic and evaluation methods. Thereafter, the management and treatment of primary risk elements of dementia are reviewed. Finally, the future perspectives of dementia (AD) focusing on the impact of the new treatment are discussed.

Original languageEnglish
Article number113168
JournalBiomedicine and Pharmacotherapy
Volume152
Early online date11 Jun 2022
DOIs
Publication statusE-pub ahead of print - 11 Jun 2022

Bibliographical note

Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Keywords

  • Alzheimer Disease/diagnosis
  • Cognitive Dysfunction/diagnosis
  • Humans
  • Tau protein
  • Neurodegenerative
  • Acetylcholine
  • Amyloid
  • Management
  • Alzheimer's disease
  • Hypothesis
  • Dementia

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