OVERLAPPING PATTERNS OF IGF2 AND H19 EXPRESSION DURING HUMAN-DEVELOPMENT - BIALLELIC IGF2 EXPRESSION CORRELATES WITH A LACK OF H19 EXPRESSION

R OHLSSON, F HEDBORG, L HOLMGREN, Colum Walsh, TJ EKSTROM

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Abstract

The spatial patterns of IGF2 and H19 gene expression are strikingly similar during parts of human embryonic/fetal and early postnatal development. Notable exceptions were found with the ciliary anlage of the embryonic retina and the choroid plexus/leptomeninges, where transcripts from the IGF2 but not the H19 locus could be detected. Moreover, in contrast to the other tissue samples examined, the choroid plexus/leptomeninges expressed both parental IGF2 alleles. Whilst RNase protection analysis revealed a weak activity of the P1 promoter in the choroid plexus/leptomeninges, the P2, P3 and P4 promoters were all active wherever IGF2 was expressed. We discuss these observations with respect to a hypothesized coordinated control of the reciprocally imprinted and closely linked IGF2 and H19 loci.
LanguageEnglish
Pages361-368
JournalDevelopment
Volume120
Issue number2
Publication statusPublished - Feb 1994

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Choroid Plexus
Human Development
Ribonucleases
Retina
Alleles
Gene Expression

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title = "OVERLAPPING PATTERNS OF IGF2 AND H19 EXPRESSION DURING HUMAN-DEVELOPMENT - BIALLELIC IGF2 EXPRESSION CORRELATES WITH A LACK OF H19 EXPRESSION",
abstract = "The spatial patterns of IGF2 and H19 gene expression are strikingly similar during parts of human embryonic/fetal and early postnatal development. Notable exceptions were found with the ciliary anlage of the embryonic retina and the choroid plexus/leptomeninges, where transcripts from the IGF2 but not the H19 locus could be detected. Moreover, in contrast to the other tissue samples examined, the choroid plexus/leptomeninges expressed both parental IGF2 alleles. Whilst RNase protection analysis revealed a weak activity of the P1 promoter in the choroid plexus/leptomeninges, the P2, P3 and P4 promoters were all active wherever IGF2 was expressed. We discuss these observations with respect to a hypothesized coordinated control of the reciprocally imprinted and closely linked IGF2 and H19 loci.",
author = "R OHLSSON and F HEDBORG and L HOLMGREN and Colum Walsh and TJ EKSTROM",
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OVERLAPPING PATTERNS OF IGF2 AND H19 EXPRESSION DURING HUMAN-DEVELOPMENT - BIALLELIC IGF2 EXPRESSION CORRELATES WITH A LACK OF H19 EXPRESSION. / OHLSSON, R; HEDBORG, F; HOLMGREN, L; Walsh, Colum; EKSTROM, TJ.

In: Development, Vol. 120, No. 2, 02.1994, p. 361-368.

Research output: Contribution to journalArticle

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AU - OHLSSON, R

AU - HEDBORG, F

AU - HOLMGREN, L

AU - Walsh, Colum

AU - EKSTROM, TJ

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AB - The spatial patterns of IGF2 and H19 gene expression are strikingly similar during parts of human embryonic/fetal and early postnatal development. Notable exceptions were found with the ciliary anlage of the embryonic retina and the choroid plexus/leptomeninges, where transcripts from the IGF2 but not the H19 locus could be detected. Moreover, in contrast to the other tissue samples examined, the choroid plexus/leptomeninges expressed both parental IGF2 alleles. Whilst RNase protection analysis revealed a weak activity of the P1 promoter in the choroid plexus/leptomeninges, the P2, P3 and P4 promoters were all active wherever IGF2 was expressed. We discuss these observations with respect to a hypothesized coordinated control of the reciprocally imprinted and closely linked IGF2 and H19 loci.

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