OVERLAPPING PATTERNS OF IGF2 AND H19 EXPRESSION DURING HUMAN-DEVELOPMENT - BIALLELIC IGF2 EXPRESSION CORRELATES WITH A LACK OF H19 EXPRESSION

R OHLSSON, F HEDBORG, L HOLMGREN, Colum Walsh, TJ EKSTROM

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119 Citations (Scopus)

Abstract

The spatial patterns of IGF2 and H19 gene expression are strikingly similar during parts of human embryonic/fetal and early postnatal development. Notable exceptions were found with the ciliary anlage of the embryonic retina and the choroid plexus/leptomeninges, where transcripts from the IGF2 but not the H19 locus could be detected. Moreover, in contrast to the other tissue samples examined, the choroid plexus/leptomeninges expressed both parental IGF2 alleles. Whilst RNase protection analysis revealed a weak activity of the P1 promoter in the choroid plexus/leptomeninges, the P2, P3 and P4 promoters were all active wherever IGF2 was expressed. We discuss these observations with respect to a hypothesized coordinated control of the reciprocally imprinted and closely linked IGF2 and H19 loci.
Original languageEnglish
Pages (from-to)361-368
JournalDevelopment
Volume120
Issue number2
Publication statusPublished - Feb 1994

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