Osteoblast-like cell response to calcium phosphate coatingchemistry and morphology on etched silicon surfaces

G Burke, C Rea, F Horgan, M Turkington, AR Boyd, BJ Meenan

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Being able to control the behaviour of osteoblast-like cells on a surface may provide a genuine insight into the material surface characteristics and help in creating a successful coating/cell interface. The possibility of creating a micro-environment that can induce proliferation, differentiation and mineralisation of bone cells in vitro, by successfully combining both chemistry and topography of a micro-fabricated substrate is an area that requires a multidisciplinary approach. Utilising sputter deposition, a process that lends itself to high processability, in conjunction with photolithography allowing for the creation of highly repeatable etched surfaces, we aim to provide a successful combination of chemistry and topography. Correlating the substrate conditions with resultant osteoblast biological function and activity can ultimately be used with a view to modulating the behavior of osteoblast-like cells in vitro.
Original languageEnglish
Pages (from-to)835-851
JournalJournal of Materials Science:Materials in Medicine
VolumeJourna
DOIs
Publication statusPublished - 28 Jan 2012

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