Being able to control the behaviour of osteoblast-like cells on a surface may provide a genuine insight into the material surface characteristics and help in creating a successful coating/cell interface. The possibility of creating a micro-environment that can induce proliferation, differentiation and mineralisation of bone cells in vitro, by successfully combining both chemistry and topography of a micro-fabricated substrate is an area that requires a multidisciplinary approach. Utilising sputter deposition, a process that lends itself to high processability, in conjunction with photolithography allowing for the creation of highly repeatable etched surfaces, we aim to provide a successful combination of chemistry and topography. Correlating the substrate conditions with resultant osteoblast biological function and activity can ultimately be used with a view to modulating the behavior of osteoblast-like cells in vitro.
|Journal||Journal of Materials Science:Materials in Medicine|
|Publication status||Published - 28 Jan 2012|
Burke, G., Rea, C., Horgan, F., Turkington, M., Boyd, AR., & Meenan, BJ. (2012). Osteoblast-like cell response to calcium phosphate coatingchemistry and morphology on etched silicon surfaces. Journal of Materials Science:Materials in Medicine, Journa, 835-851. https://doi.org/10.1007/s10856-011-4542-x