TY - JOUR
T1 - Osteoblast-like cell response to calcium phosphate coatingchemistry and morphology on etched silicon surfaces
AU - Burke, G
AU - Rea, C
AU - Horgan, F
AU - Turkington, M
AU - Boyd, AR
AU - Meenan, BJ
PY - 2012/1/28
Y1 - 2012/1/28
N2 - Being able to control the behaviour of osteoblast-like cells on a surface may provide a genuine insight into the material surface characteristics and help in creating a successful coating/cell interface. The possibility of creating a micro-environment that can induce proliferation, differentiation and mineralisation of bone cells in vitro, by successfully combining both chemistry and topography of a micro-fabricated substrate is an area that requires a multidisciplinary approach. Utilising sputter deposition, a process that lends itself to high processability, in conjunction with photolithography allowing for the creation of highly repeatable etched surfaces, we aim to provide a successful combination of chemistry and topography. Correlating the substrate conditions with resultant osteoblast biological function and activity can ultimately be used with a view to modulating the behavior of osteoblast-like cells in vitro.
AB - Being able to control the behaviour of osteoblast-like cells on a surface may provide a genuine insight into the material surface characteristics and help in creating a successful coating/cell interface. The possibility of creating a micro-environment that can induce proliferation, differentiation and mineralisation of bone cells in vitro, by successfully combining both chemistry and topography of a micro-fabricated substrate is an area that requires a multidisciplinary approach. Utilising sputter deposition, a process that lends itself to high processability, in conjunction with photolithography allowing for the creation of highly repeatable etched surfaces, we aim to provide a successful combination of chemistry and topography. Correlating the substrate conditions with resultant osteoblast biological function and activity can ultimately be used with a view to modulating the behavior of osteoblast-like cells in vitro.
U2 - 10.1007/s10856-011-4542-x
DO - 10.1007/s10856-011-4542-x
M3 - Article
SN - 1573-4838
VL - Journa
SP - 835
EP - 851
JO - Journal of Materials Science:Materials in Medicine
JF - Journal of Materials Science:Materials in Medicine
ER -