Organized Modularity in the Interactome: Evidence from the Analysis of Dynamic Organization in the Cell Cycle

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The organization of global protein interaction networks (PINs) has been extensively studied and heatedly debated. We revisited this issue in the context of the analysis of dynamic organization of a PIN in the yeast cell cycle. Statistically significant bimodality was observed when analyzing the distribution of the differences in expression peak between periodically expressed partners. A close look at their behavior revealed that date and party hubs derived from this analysis have some distinct features. There are no significant differences between them in terms of protein essentiality, expression correlation and semantic similarity derived from Gene Ontology (GO) biological process hierarchy. However, date hubs exhibit significantly greater values than party hubs in terms of semantic similarity derived from both GO molecular function and cellular component hierarchies. Relating to three-dimensional structures, we found that both single - and multi-interface proteins could become date hubs coordinating multiple functions performed at different times while party hubs are mainly multi-interface proteins. Furthermore, we constructed and analyzed a PPI network specific to the human cell cycle and highlighted that the dynamic organization in human interactome is far more complex than the dichotomy of hubs observed in the yeast cell cycle.
Original languageEnglish
Pages (from-to)1264-1270
Number of pages8
JournalIEEE/ACM Transactions on Computational Biology and Bioinformatics
Volume11
Issue number6
Early online date23 Apr 2014
DOIs
Publication statusPublished - Nov 2014

Fingerprint Dive into the research topics of 'Organized Modularity in the Interactome: Evidence from the Analysis of Dynamic Organization in the Cell Cycle'. Together they form a unique fingerprint.

  • Cite this