Abstract
Introduction: Oral administration of a drug is the most common, ideal and preferred route of administration. The main problem of oral drug formulations is their low bioavailability arises from poor aqueous solubility of drug. Aqueous solubility of lipophilic drugs can be improved by various techniques like salt formation, complexation, addition of co-solvent etc. but self-emulsifying drug delivery system (SEDDS) is getting more attention for increasing the solubility of such drugs. The SEDDS is an isotropic mixture of drug, lipids, and emulsifiers, usually with one or more hydrophilic co-solvents/co-emulsifiers. This system is having the ability to generate oil-in-water (o/w) emulsions or microemulsions upon gentle agitation followed by dilution with an aqueous phase. The SEDDSs are relatively newer, lipid-based technological innovations possessing unparalleled potential in improving oral bioavailability of poorly water-soluble drugs.
Areas covered: This review provides updated information regarding the types of SEDDS, their preparation techniques, drug delivery and related recent patents along with marketed formulations.
Expert opinion: The SEDDS has been explored for improving bioavailability, rising intra-subject heterogeneity and increasing solubility. SEDDS offers the benefit of a protective effect against the hostile environment in the gut. The unique fabrication techniques provide specific strategy to overcome the low bioavailability and poor solubility problems.
Areas covered: This review provides updated information regarding the types of SEDDS, their preparation techniques, drug delivery and related recent patents along with marketed formulations.
Expert opinion: The SEDDS has been explored for improving bioavailability, rising intra-subject heterogeneity and increasing solubility. SEDDS offers the benefit of a protective effect against the hostile environment in the gut. The unique fabrication techniques provide specific strategy to overcome the low bioavailability and poor solubility problems.
Original language | English |
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Number of pages | 54 |
Journal | Expert Opinion on Drug Delivery |
Early online date | 24 Nov 2020 |
DOIs | |
Publication status | Published - 24 Nov 2020 |
Keywords
- Pharmaceutical Science