Orally administered self-emulsifying drug delivery system in disease management: Advancement and patents

Vijay Mishra, Pallavi Nayak, Nishika Yadav, Manvendra Singh, Murtaza M. Tambuwala, Alaa A. A. Aljabali

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
2 Downloads (Pure)

Abstract

Introduction: Oral administration of a drug is the most common, ideal and preferred route of administration. The main problem of oral drug formulations is their low bioavailability arises from poor aqueous solubility of drug. Aqueous solubility of lipophilic drugs can be improved by various techniques like salt formation, complexation, addition of co-solvent etc. but self-emulsifying drug-delivery system (SEDDS) is getting more attention for increasing the solubility of such drugs. The SEDDS is an isotropic mixture of drug, lipids, and emulsifiers, usually with one or more hydrophilic co-solvents/co-emulsifiers. This system is having ability to generate oil-in-water (o/w) emulsions or microemulsions upon gentle agitation followed by dilution with aqueous phase. The SEDDSs are relatively newer, lipid-based technological innovations possessing unparalleled potential in improving oral bioavailability of poorly water-soluble drugs. 

Areas covered: This review provides updated information regarding the types of SEDDS, their preparation techniques, drug delivery and related recent patents along with marketed formulations. 

Expert opinion: The SEDDS has been explored for improving bioavailability, rising intra-subject heterogeneity, and increasing solubility. SEDDS offers the benefit of a protective effect against the hostile environment in the gut. The unique fabrication techniques provide specific strategy to overcome the low bioavailability and poor solubility problems.

Original languageEnglish
Pages (from-to)315-332
Number of pages18
JournalExpert Opinion on Drug Delivery
Volume18
Issue number3
Early online date24 Nov 2020
DOIs
Publication statusPublished - 1 Dec 2020

Keywords

  • Self-emulsifying drug-delivery system
  • bioavailability
  • drug delivery
  • patents
  • solubility

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