Obesity is associated with reduced cerebral blood flow – modified by physical activity

Silvin P. Knight; Eamon Laird; Wilby Williamson; John O'Connor; Louise Newman; Daniel Carey; Celine De Looze; Andrew J. Fagan; Michael A. Chappell; James F. Meaney; Rose Anne Kenny

doi:10.1016/j.neurobiolaging.2021.04.008

Obesity is associated with reduced cerebral blood flow – modified by physical activity

Silvin P. Knight, Eamon Laird, Wilby Williamson, John O'Connor, Louise Newman, Daniel Carey, Celine De Looze, Andrew J. Fagan, Michael A. Chappell, James F. Meaney, Rose Anne Kenny

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

This study examined the associations of body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC), and physical activity (PA) with gray matter cerebral blood flow (CBF_GM) in older adults. Cross-sectional data was used from the Irish Longitudinal Study on Ageing (n = 495, age 69.0 ±7.4 years, 52.1% female). Whole-brain CBF_GM was quantified using arterial spin labeling MRI. Results from multivariable regression analysis revealed that an increase in BMI of 0.43 kg/m², WHR of 0.01, or WC of 1.3 cm were associated with the same reduction in CBF_GM as 1 year of advancing age. Participants overweight by BMI or with high WHR/WC reporting low/moderate PA had up to 3 ml/100g/min lower CBF_GM (p ≤.011); there was no significant reduction for those reporting high PA. Since PA could potentially moderate obesity/CBF associations, this may be a cost-effective and relatively easy way to help mitigate the negative impact of obesity in an older population, such as cerebral hypoperfusion, which is an early mechanism in vascular dementia and Alzheimer's disease.

Original language	English
Pages (from-to)	35-47
Number of pages	13
Journal	Neurobiology of Aging
Volume	105
Early online date	22 Apr 2021
DOIs	https://doi.org/10.1016/j.neurobiolaging.2021.04.008
Publication status	Published (in print/issue) - 1 Sept 2021

Bibliographical note

Publisher Copyright:
© 2021 The Author(s)

Keywords

Arterial spin labeling MRI
Cerebral blood flow
Cerebral perfusion
Obesity
Physical activity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.neurobiolaging.2021.04.008

1-s2.0-S0197458021001238-mainFinal published version, 1.64 MBLicence: CC BY

Cite this

@article{9aa9c64097a143d695ca0d25eab1b5d4,

title = "Obesity is associated with reduced cerebral blood flow – modified by physical activity",

abstract = "This study examined the associations of body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC), and physical activity (PA) with gray matter cerebral blood flow (CBFGM) in older adults. Cross-sectional data was used from the Irish Longitudinal Study on Ageing (n = 495, age 69.0 ±7.4 years, 52.1% female). Whole-brain CBFGM was quantified using arterial spin labeling MRI. Results from multivariable regression analysis revealed that an increase in BMI of 0.43 kg/m2, WHR of 0.01, or WC of 1.3 cm were associated with the same reduction in CBFGM as 1 year of advancing age. Participants overweight by BMI or with high WHR/WC reporting low/moderate PA had up to 3 ml/100g/min lower CBFGM (p ≤.011); there was no significant reduction for those reporting high PA. Since PA could potentially moderate obesity/CBF associations, this may be a cost-effective and relatively easy way to help mitigate the negative impact of obesity in an older population, such as cerebral hypoperfusion, which is an early mechanism in vascular dementia and Alzheimer's disease.",

keywords = "Arterial spin labeling MRI, Cerebral blood flow, Cerebral perfusion, Obesity, Physical activity",

author = "Knight, {Silvin P.} and Eamon Laird and Wilby Williamson and John O'Connor and Louise Newman and Daniel Carey and {De Looze}, Celine and Fagan, {Andrew J.} and Chappell, {Michael A.} and Meaney, {James F.} and Kenny, {Rose Anne}",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s)",

year = "2021",

month = sep,

day = "1",

doi = "10.1016/j.neurobiolaging.2021.04.008",

language = "English",

volume = "105",

pages = "35--47",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Obesity is associated with reduced cerebral blood flow – modified by physical activity

AU - Knight, Silvin P.

AU - Laird, Eamon

AU - Williamson, Wilby

AU - O'Connor, John

AU - Newman, Louise

AU - Carey, Daniel

AU - De Looze, Celine

AU - Fagan, Andrew J.

AU - Chappell, Michael A.

AU - Meaney, James F.

AU - Kenny, Rose Anne

PY - 2021/9/1

Y1 - 2021/9/1

N2 - This study examined the associations of body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC), and physical activity (PA) with gray matter cerebral blood flow (CBFGM) in older adults. Cross-sectional data was used from the Irish Longitudinal Study on Ageing (n = 495, age 69.0 ±7.4 years, 52.1% female). Whole-brain CBFGM was quantified using arterial spin labeling MRI. Results from multivariable regression analysis revealed that an increase in BMI of 0.43 kg/m2, WHR of 0.01, or WC of 1.3 cm were associated with the same reduction in CBFGM as 1 year of advancing age. Participants overweight by BMI or with high WHR/WC reporting low/moderate PA had up to 3 ml/100g/min lower CBFGM (p ≤.011); there was no significant reduction for those reporting high PA. Since PA could potentially moderate obesity/CBF associations, this may be a cost-effective and relatively easy way to help mitigate the negative impact of obesity in an older population, such as cerebral hypoperfusion, which is an early mechanism in vascular dementia and Alzheimer's disease.

AB - This study examined the associations of body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC), and physical activity (PA) with gray matter cerebral blood flow (CBFGM) in older adults. Cross-sectional data was used from the Irish Longitudinal Study on Ageing (n = 495, age 69.0 ±7.4 years, 52.1% female). Whole-brain CBFGM was quantified using arterial spin labeling MRI. Results from multivariable regression analysis revealed that an increase in BMI of 0.43 kg/m2, WHR of 0.01, or WC of 1.3 cm were associated with the same reduction in CBFGM as 1 year of advancing age. Participants overweight by BMI or with high WHR/WC reporting low/moderate PA had up to 3 ml/100g/min lower CBFGM (p ≤.011); there was no significant reduction for those reporting high PA. Since PA could potentially moderate obesity/CBF associations, this may be a cost-effective and relatively easy way to help mitigate the negative impact of obesity in an older population, such as cerebral hypoperfusion, which is an early mechanism in vascular dementia and Alzheimer's disease.

KW - Arterial spin labeling MRI

KW - Cerebral blood flow

KW - Cerebral perfusion

KW - Obesity

KW - Physical activity

UR - http://www.scopus.com/inward/record.url?scp=85107646092&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2021.04.008

DO - 10.1016/j.neurobiolaging.2021.04.008

M3 - Article

C2 - 34022537

AN - SCOPUS:85107646092

SN - 0197-4580

VL - 105

SP - 35

EP - 47

JO - Neurobiology of Aging

JF - Neurobiology of Aging

ER -

Obesity is associated with reduced cerebral blood flow – modified by physical activity

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this