Obesity and inflammation: the effects of weight loss

    Research output: Contribution to journalArticle

    192 Citations (Scopus)

    Abstract

    Following the discovery of TNF-alpha and leptin as secretory products of adipocytes in the early 1990s. subsequent obesity research focused on the new functional role of adipose tissue. as an active endocrine or.-an. Many more inflammatory peptides have been linked to adiposity, which ultimately characterised obesity as a state of low-grade systemic inflammation, or `metaflammation' which may link obesity to its co-morbidities. The aim of the present review is to examine the effects of weight loss on inflammation in overweight and obese, but otherwise healthy, Populations. Studies were broadly classified into four types (diet, physical activity, diet and physical activity combined, and surgical interventions) and discussed according to the method used to induce weight loss. All studies measured at least one obesity-related inflammatory marker (ORIM). The overall finding from the present review is that weight loss does improve inflammation in terms of both the inflammatory (C-reactive protein, TNF-alpha, IL-6 and leptin) and anti-inflammatory (adiponectin) ORIM. Within this, the greatest improvements in ORIM are observed in studies achieving a weight loss of at least 10%. However, a number of methodological issues have been identified its potential limitations within the literature including the sex and age of subjects, sample size, study duration and the assessment of body composition. In conclusion, although a period of weight loss per se is capable of reversing the unfavourable inflammatory profile evident in the obese state, further Studies are required to determine the time needed, in which a reduced weight is maintained, in order to benefit from improved inflammatory status long term.
    LanguageEnglish
    Pages117-133
    JournalNutrition Research Reviews
    Volume21
    Issue number2
    DOIs
    Publication statusPublished - Dec 2008

    Fingerprint

    Weight Loss
    Obesity
    Inflammation
    Leptin
    Tumor Necrosis Factor-alpha
    Adiponectin
    Adiposity
    Body Composition
    Adipocytes
    C-Reactive Protein
    Sample Size
    Adipose Tissue
    Interleukin-6
    Anti-Inflammatory Agents
    Diet
    Morbidity
    Weights and Measures
    Peptides
    Research
    Population

    Cite this

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    title = "Obesity and inflammation: the effects of weight loss",
    abstract = "Following the discovery of TNF-alpha and leptin as secretory products of adipocytes in the early 1990s. subsequent obesity research focused on the new functional role of adipose tissue. as an active endocrine or.-an. Many more inflammatory peptides have been linked to adiposity, which ultimately characterised obesity as a state of low-grade systemic inflammation, or `metaflammation' which may link obesity to its co-morbidities. The aim of the present review is to examine the effects of weight loss on inflammation in overweight and obese, but otherwise healthy, Populations. Studies were broadly classified into four types (diet, physical activity, diet and physical activity combined, and surgical interventions) and discussed according to the method used to induce weight loss. All studies measured at least one obesity-related inflammatory marker (ORIM). The overall finding from the present review is that weight loss does improve inflammation in terms of both the inflammatory (C-reactive protein, TNF-alpha, IL-6 and leptin) and anti-inflammatory (adiponectin) ORIM. Within this, the greatest improvements in ORIM are observed in studies achieving a weight loss of at least 10{\%}. However, a number of methodological issues have been identified its potential limitations within the literature including the sex and age of subjects, sample size, study duration and the assessment of body composition. In conclusion, although a period of weight loss per se is capable of reversing the unfavourable inflammatory profile evident in the obese state, further Studies are required to determine the time needed, in which a reduced weight is maintained, in order to benefit from improved inflammatory status long term.",
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    Obesity and inflammation: the effects of weight loss. / Forsythe, L. Kirsty; Wallace, Julie; Livingstone, Barbara.

    In: Nutrition Research Reviews, Vol. 21, No. 2, 12.2008, p. 117-133.

    Research output: Contribution to journalArticle

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