Nutrient Release from Printable Tissue Engineering Scaffolds

Kieran O'Donnell, Matthew Wilson, BJ Meenan

Research output: Contribution to conferenceAbstract

Abstract

Within tissue engineering, the scalability of current model scaffolds for the treatment of critical bone defects is a major limitation. The scaffold pore size allows for successful in vitro performance, but when scaled for in vivo testing the overall porosity that allows successful diffusion of nutrients from the periphery to the core is insufficient due to the build-up of cellular effluent. This restricted diffusion causes formation of a ‘necrotic core’ within the scaffold, resulting in cell death.
Through the development of multi-layered hybrid scaffolds, this research addresses this concern by providing adhesion sites and sufficient overall porosity promoting cellular adhesion, proliferation and efficient nutrient exchange. To date this work has focused on the polymerisation of commercially available blends of poly(ethylene glycol) diacrylates of low molecular weights, through near-UV wavelengths to exploit the resultant variances of pore sizes, allowing for increased diffusion through the scaffold component layer.

Conference

Conference2nd Annual 3D printing & Bio-printing in Healthcare Conference
CountryGermany
CityDusseldorf
Period12/10/1713/10/17

Fingerprint

Tissue Scaffolds
Tissue Engineering
Porosity
Food
Polymerization
Cell Death
Molecular Weight
Cell Proliferation
Bone and Bones
Research

Cite this

O'Donnell, K., Wilson, M., & Meenan, BJ. (Accepted/In press). Nutrient Release from Printable Tissue Engineering Scaffolds. Abstract from 2nd Annual 3D printing & Bio-printing in Healthcare Conference, Dusseldorf, Germany.
O'Donnell, Kieran ; Wilson, Matthew ; Meenan, BJ. / Nutrient Release from Printable Tissue Engineering Scaffolds. Abstract from 2nd Annual 3D printing & Bio-printing in Healthcare Conference, Dusseldorf, Germany.
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abstract = "Within tissue engineering, the scalability of current model scaffolds for the treatment of critical bone defects is a major limitation. The scaffold pore size allows for successful in vitro performance, but when scaled for in vivo testing the overall porosity that allows successful diffusion of nutrients from the periphery to the core is insufficient due to the build-up of cellular effluent. This restricted diffusion causes formation of a ‘necrotic core’ within the scaffold, resulting in cell death. Through the development of multi-layered hybrid scaffolds, this research addresses this concern by providing adhesion sites and sufficient overall porosity promoting cellular adhesion, proliferation and efficient nutrient exchange. To date this work has focused on the polymerisation of commercially available blends of poly(ethylene glycol) diacrylates of low molecular weights, through near-UV wavelengths to exploit the resultant variances of pore sizes, allowing for increased diffusion through the scaffold component layer.",
author = "Kieran O'Donnell and Matthew Wilson and BJ Meenan",
note = "Conference paper and poster; 2nd Annual 3D printing & Bio-printing in Healthcare Conference ; Conference date: 12-10-2017 Through 13-10-2017",
year = "2017",
language = "English",

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O'Donnell, K, Wilson, M & Meenan, BJ 2017, 'Nutrient Release from Printable Tissue Engineering Scaffolds' 2nd Annual 3D printing & Bio-printing in Healthcare Conference, Dusseldorf, Germany, 12/10/17 - 13/10/17, .

Nutrient Release from Printable Tissue Engineering Scaffolds. / O'Donnell, Kieran; Wilson, Matthew; Meenan, BJ.

2017. Abstract from 2nd Annual 3D printing & Bio-printing in Healthcare Conference, Dusseldorf, Germany.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Nutrient Release from Printable Tissue Engineering Scaffolds

AU - O'Donnell, Kieran

AU - Wilson, Matthew

AU - Meenan, BJ

N1 - Conference paper and poster

PY - 2017

Y1 - 2017

N2 - Within tissue engineering, the scalability of current model scaffolds for the treatment of critical bone defects is a major limitation. The scaffold pore size allows for successful in vitro performance, but when scaled for in vivo testing the overall porosity that allows successful diffusion of nutrients from the periphery to the core is insufficient due to the build-up of cellular effluent. This restricted diffusion causes formation of a ‘necrotic core’ within the scaffold, resulting in cell death. Through the development of multi-layered hybrid scaffolds, this research addresses this concern by providing adhesion sites and sufficient overall porosity promoting cellular adhesion, proliferation and efficient nutrient exchange. To date this work has focused on the polymerisation of commercially available blends of poly(ethylene glycol) diacrylates of low molecular weights, through near-UV wavelengths to exploit the resultant variances of pore sizes, allowing for increased diffusion through the scaffold component layer.

AB - Within tissue engineering, the scalability of current model scaffolds for the treatment of critical bone defects is a major limitation. The scaffold pore size allows for successful in vitro performance, but when scaled for in vivo testing the overall porosity that allows successful diffusion of nutrients from the periphery to the core is insufficient due to the build-up of cellular effluent. This restricted diffusion causes formation of a ‘necrotic core’ within the scaffold, resulting in cell death. Through the development of multi-layered hybrid scaffolds, this research addresses this concern by providing adhesion sites and sufficient overall porosity promoting cellular adhesion, proliferation and efficient nutrient exchange. To date this work has focused on the polymerisation of commercially available blends of poly(ethylene glycol) diacrylates of low molecular weights, through near-UV wavelengths to exploit the resultant variances of pore sizes, allowing for increased diffusion through the scaffold component layer.

M3 - Abstract

ER -

O'Donnell K, Wilson M, Meenan BJ. Nutrient Release from Printable Tissue Engineering Scaffolds. 2017. Abstract from 2nd Annual 3D printing & Bio-printing in Healthcare Conference, Dusseldorf, Germany.