Nutrient Release from Printable Tissue Engineering Scaffolds

Kieran O'Donnell, Matthew Wilson, BJ Meenan

Research output: Contribution to conferenceAbstract

Abstract

Within tissue engineering, the scalability of current model scaffolds for the treatment of critical bone defects is a major limitation. The scaffold pore size allows for successful in vitro performance, but when scaled for in vivo testing the overall porosity that allows successful diffusion of nutrients from the periphery to the core is insufficient due to the build-up of cellular effluent. This restricted diffusion causes formation of a ‘necrotic core’ within the scaffold, resulting in cell death.
Through the development of multi-layered hybrid scaffolds, this research addresses this concern by providing adhesion sites and sufficient overall porosity promoting cellular adhesion, proliferation and efficient nutrient exchange. To date this work has focused on the polymerisation of commercially available blends of poly(ethylene glycol) diacrylates of low molecular weights, through near-UV wavelengths to exploit the resultant variances of pore sizes, allowing for increased diffusion through the scaffold component layer.
Original languageEnglish
Publication statusAccepted/In press - 2017
Event2nd Annual 3D printing & Bio-printing in Healthcare Conference - Holiday Inn Dusseldorf Airport-Ratingen, Dusseldorf, Germany
Duration: 12 Oct 201713 Oct 2017

Conference

Conference2nd Annual 3D printing & Bio-printing in Healthcare Conference
CountryGermany
CityDusseldorf
Period12/10/1713/10/17

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    O'Donnell, K., Wilson, M., & Meenan, BJ. (Accepted/In press). Nutrient Release from Printable Tissue Engineering Scaffolds. Abstract from 2nd Annual 3D printing & Bio-printing in Healthcare Conference, Dusseldorf, Germany.