Nucleus Segmentation and Classification using Residual SE-UNet and Feature Concatenation Approach in Cervical Cytopathology Cell images

Jignesh Chowdary, Suganya G, Premalatha M, Pratheepan Yogarajah

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Introduction: Pap smear is considered to be the primary examination for the diagnosis of cervical cancer. But the analysis of pap smear slides is a time-consuming task and tedious as it requires manual intervention. The diagnostic efficiency depends on the medical expertise of the pathologist, and human error often hinders the diagnosis. Automated segmentation and classification of cervical nuclei will help diagnose cervical cancer in earlier stages. Materials and Methods: The proposed methodology includes three models: a Residual-Squeeze-and-Excitation-module based segmentation model, a fusion-based feature extraction model, and a Multi-layer Perceptron classification model. In the fusion-based feature extraction model, three sets of deep features are extracted from these segmented nuclei using the pre-trained and fine-tuned VGG19, VGG-F, and CaffeNet models, and two hand-crafted descriptors, Bag-of-Features and Linear-Binary-Patterns, are extracted for each image. For this work, Herlev, SIPaKMeD, and ISBI2014 datasets are used for evaluation. The Herlev datasetis used for evaluating both segmentation and classification models. Whereas the SIPaKMeD and ISBI2014 are used for evaluating the classification model, and the segmentation model respectively. Results: The segmentation network enhanced the precision and ZSI by 2.04%, and 2.00% on the Herlev dataset, and the precision and recall by 0.68%, and 2.59% on the ISBI2014 dataset. The classification approach enhanced the accuracy, recall, and specificity by 0.59%, 0.47%, and 1.15% on the Herlev dataset, and by 0.02%, 0.15%, and 0.22% on the SIPaKMed dataset. Conclusion: The experiments demonstrate that the proposed work achieves promising performance on segmentation and classification in cervical cytopathology cell images..
Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalTechnology in Cancer Research and Treatment
Early online date6 Feb 2023
Publication statusPublished online - 6 Feb 2023

Bibliographical note

Funding Information:
The author(s) disclosed receipt of the following financial support for the publication of this article: The authors are thankful for the financial support provided by the Intelligent Systems Research Centre (ISRC), Ulster University, UK.

Publisher Copyright:
© The Author(s) 2023.


  • Cervical cancer
  • pap smear
  • deep learning
  • segmentation
  • transfer learning


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