Nucleic acid enzymes: The fusion of self-assembly and conformational computing

E. Ramlan, Klaus Peter Zauner

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Macromolecules are the predominant physical substrate supporting information processing in organisms. Two key characteristics-conformational dynamics and self-assembly properties-render macromolecules unique in this context. Both characteristics have been investigated for technical applications. In nature's information processors self-assembly and conformational switching commonly appear in combination and are typically realised with proteins. At the current state of biotechnology the best candidates for implementing artifical molecular information process-ing systems that utilise the combination self-assembly and conformational switching are functional nucleic acids. The increasingly realised preva-lence of oligonucleotides in intracellular control points towards potential applications. The present paper reviews approaches to integrating the self-assembly and the conformational paradigm with allosterically controlled nucleic acid enzymes. It also introduces a new computational workflow to design functional nucleic acids for information processing.

LanguageEnglish
Pages165-189
Number of pages25
JournalInternational Journal of Unconventional Computing
Volume5
Issue number2
Publication statusPublished - 1 Dec 2009

Fingerprint

Nucleic acids
Self assembly
Fusion reactions
Enzymes
Macromolecules
Oligonucleotides
Biotechnology
Proteins
Substrates

Keywords

  • Allosteric control
  • Deoxyribozymes
  • Logic gates
  • Molecular computing
  • Ribozymes

Cite this

Ramlan, E. ; Zauner, Klaus Peter. / Nucleic acid enzymes : The fusion of self-assembly and conformational computing. 2009 ; Vol. 5, No. 2. pp. 165-189.
@article{7e20c24b9e3248628b9cbcfc53088ed4,
title = "Nucleic acid enzymes: The fusion of self-assembly and conformational computing",
abstract = "Macromolecules are the predominant physical substrate supporting information processing in organisms. Two key characteristics-conformational dynamics and self-assembly properties-render macromolecules unique in this context. Both characteristics have been investigated for technical applications. In nature's information processors self-assembly and conformational switching commonly appear in combination and are typically realised with proteins. At the current state of biotechnology the best candidates for implementing artifical molecular information process-ing systems that utilise the combination self-assembly and conformational switching are functional nucleic acids. The increasingly realised preva-lence of oligonucleotides in intracellular control points towards potential applications. The present paper reviews approaches to integrating the self-assembly and the conformational paradigm with allosterically controlled nucleic acid enzymes. It also introduces a new computational workflow to design functional nucleic acids for information processing.",
keywords = "Allosteric control, Deoxyribozymes, Logic gates, Molecular computing, Ribozymes",
author = "E. Ramlan and Zauner, {Klaus Peter}",
year = "2009",
month = "12",
day = "1",
language = "English",
volume = "5",
pages = "165--189",
number = "2",

}

Nucleic acid enzymes : The fusion of self-assembly and conformational computing. / Ramlan, E.; Zauner, Klaus Peter.

Vol. 5, No. 2, 01.12.2009, p. 165-189.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nucleic acid enzymes

T2 - The fusion of self-assembly and conformational computing

AU - Ramlan, E.

AU - Zauner, Klaus Peter

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Macromolecules are the predominant physical substrate supporting information processing in organisms. Two key characteristics-conformational dynamics and self-assembly properties-render macromolecules unique in this context. Both characteristics have been investigated for technical applications. In nature's information processors self-assembly and conformational switching commonly appear in combination and are typically realised with proteins. At the current state of biotechnology the best candidates for implementing artifical molecular information process-ing systems that utilise the combination self-assembly and conformational switching are functional nucleic acids. The increasingly realised preva-lence of oligonucleotides in intracellular control points towards potential applications. The present paper reviews approaches to integrating the self-assembly and the conformational paradigm with allosterically controlled nucleic acid enzymes. It also introduces a new computational workflow to design functional nucleic acids for information processing.

AB - Macromolecules are the predominant physical substrate supporting information processing in organisms. Two key characteristics-conformational dynamics and self-assembly properties-render macromolecules unique in this context. Both characteristics have been investigated for technical applications. In nature's information processors self-assembly and conformational switching commonly appear in combination and are typically realised with proteins. At the current state of biotechnology the best candidates for implementing artifical molecular information process-ing systems that utilise the combination self-assembly and conformational switching are functional nucleic acids. The increasingly realised preva-lence of oligonucleotides in intracellular control points towards potential applications. The present paper reviews approaches to integrating the self-assembly and the conformational paradigm with allosterically controlled nucleic acid enzymes. It also introduces a new computational workflow to design functional nucleic acids for information processing.

KW - Allosteric control

KW - Deoxyribozymes

KW - Logic gates

KW - Molecular computing

KW - Ribozymes

UR - http://www.scopus.com/inward/record.url?scp=77952492438&partnerID=8YFLogxK

M3 - Article

VL - 5

SP - 165

EP - 189

IS - 2

ER -