Nucleic acid aptamers as potential Nucleus targeted drug delivery system

Garima Shrivastava, Hamid A. Bakshi, Alaa A. Aljabali, Vijay Mishra, Lukmanul Hakkim Faruck, Nitin B. Charbe, Prashant Kesharwani, Dinesh Kumar Chellappan, Kamal Dua, Murtaza M. Tambuwala

Research output: Contribution to journalArticle

Abstract

Background: Nucleus targeted drug delivery presents several opportunities for the treatment of fatal diseases such as cancer. However, the complex nucleocytoplasmic barriers pose significant challenges for delivering a drug directly and efficiently into the nucleus. Aptamers representing single-stranded DNA and RNA qualify as next-generation highly advanced and personalized medicinal agents that successfully inhibit the expression of certain proteins; possess extraordinary gene-expression for manoeuvring the diseased cell's fate with negligible toxicity. In addition, the precisely directed aptamers to the site of action present a tremendous potential to reach the nucleus by escaping the ensuing barriers to exhibit a better drug activity and gene expression.

Objective: This review epigrammatically highlights the significance of targeted drug delivery and presents a comprehensive description of the principle barriers faced by nucleus targeted drug delivery paradigm and ensuing complexities thereof. Eventually, the progress of nucleus targeting with nucleic acid aptamers and success achieved so far have also been reviewed.

Method: Systematic literature search of research published till date in the field of nucleic acid aptamers.

Results and Conclusion: The review specifically points out the contribution of individual aptamers as the nucleus-targeting agent rather than aptamers in conjugated form.
LanguageEnglish
Number of pages11
JournalCurrent Drug Delivery
Volume17
DOIs
Publication statusAccepted/In press - 6 Jan 2020

Fingerprint

Drug Delivery Systems
Nucleic Acids
Pharmaceutical Preparations
Gene Expression
Single-Stranded DNA
RNA
Research
Neoplasms
Proteins
Therapeutics

Keywords

  • Nucleus
  • RNA aptamers
  • Nucleic acid aptamers
  • Proteins
  • Nucleus targeting DNA
  • Nucleus targeted drug delivery

Cite this

Shrivastava, Garima ; Bakshi, Hamid A. ; Aljabali, Alaa A. ; Mishra, Vijay ; Faruck, Lukmanul Hakkim ; Charbe, Nitin B. ; Kesharwani, Prashant ; Chellappan, Dinesh Kumar ; Dua, Kamal ; Tambuwala, Murtaza M. / Nucleic acid aptamers as potential Nucleus targeted drug delivery system. In: Current Drug Delivery. 2020 ; Vol. 17.
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Shrivastava, G, Bakshi, HA, Aljabali, AA, Mishra, V, Faruck, LH, Charbe, NB, Kesharwani, P, Chellappan, DK, Dua, K & Tambuwala, MM 2020, 'Nucleic acid aptamers as potential Nucleus targeted drug delivery system', Current Drug Delivery, vol. 17. https://doi.org/10.2174/1567201817666200106104332

Nucleic acid aptamers as potential Nucleus targeted drug delivery system. / Shrivastava, Garima; Bakshi, Hamid A.; Aljabali, Alaa A.; Mishra, Vijay; Faruck, Lukmanul Hakkim; Charbe, Nitin B.; Kesharwani, Prashant; Chellappan, Dinesh Kumar; Dua, Kamal; Tambuwala, Murtaza M.

In: Current Drug Delivery, Vol. 17, 06.01.2020.

Research output: Contribution to journalArticle

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AU - Faruck, Lukmanul Hakkim

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AU - Kesharwani, Prashant

AU - Chellappan, Dinesh Kumar

AU - Dua, Kamal

AU - Tambuwala, Murtaza M.

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