TY - JOUR
T1 - Nucleic Acid Aptamers as a Potential Nucleus Targeted Drug Delivery System
AU - Shrivastava, Garima
AU - Bakshi, Hamid A.
AU - Aljabali, Alaa A.
AU - Mishra, Vijay
AU - Faruck, Lukmanul Hakkim
AU - Charbe, Nitin B.
AU - Kesharwani, Prashant
AU - Chellappan, Dinesh Kumar
AU - Dua, Kamal
AU - Tambuwala, Murtaza M.
PY - 2020/1/31
Y1 - 2020/1/31
N2 - Background: Nucleus targeted drug delivery provides several opportunities for the treatment of fatal diseases such as cancer. However, the complex nucleocytoplasmic barriers pose significant challenges for delivering a drug directly and efficiently into the nucleus. Aptamers representing single-stranded DNA and RNA qualify as next-generation highly advanced and personalized medicinal agents that successfully inhibit the expression of certain proteins; possess extraordinary gene-expression for manoeuvring the diseased cell's fate with negligible toxicity. In addition, the precisely directed aptam-ers to the site of action present a tremendous potential to reach the nucleus by escaping the ensuing barriers to exhibit a better drug activity and gene expression. Objective: This review epigrammatically highlights the significance of targeted drug delivery and pre-sents a comprehensive description of the principal barriers faced by the nucleus targeted drug delivery paradigm and ensuing complexities thereof. Eventually, the progress of nucleus targeting with nucleic acid aptamers and success achieved so far have also been reviewed. Methods: Systematic literature search was conducted of research published to date in the field of nucleic acid aptamers. Results and Conclusion: The review specifically points out the contribution of individual aptamers as the nucleus-targeting agent rather than aptamers in conjugated form.
AB - Background: Nucleus targeted drug delivery provides several opportunities for the treatment of fatal diseases such as cancer. However, the complex nucleocytoplasmic barriers pose significant challenges for delivering a drug directly and efficiently into the nucleus. Aptamers representing single-stranded DNA and RNA qualify as next-generation highly advanced and personalized medicinal agents that successfully inhibit the expression of certain proteins; possess extraordinary gene-expression for manoeuvring the diseased cell's fate with negligible toxicity. In addition, the precisely directed aptam-ers to the site of action present a tremendous potential to reach the nucleus by escaping the ensuing barriers to exhibit a better drug activity and gene expression. Objective: This review epigrammatically highlights the significance of targeted drug delivery and pre-sents a comprehensive description of the principal barriers faced by the nucleus targeted drug delivery paradigm and ensuing complexities thereof. Eventually, the progress of nucleus targeting with nucleic acid aptamers and success achieved so far have also been reviewed. Methods: Systematic literature search was conducted of research published to date in the field of nucleic acid aptamers. Results and Conclusion: The review specifically points out the contribution of individual aptamers as the nucleus-targeting agent rather than aptamers in conjugated form.
KW - Nucleus
KW - Nucleus targeted drug delivery
KW - Nucleus targeting DNA
KW - Proteins
KW - Nucleic acid aptamers
KW - RNA aptamers
UR - http://www.scopus.com/inward/record.url?scp=85081945770&partnerID=8YFLogxK
UR - http://www.eurekaselect.com/178088/article
UR - https://www.ncbi.nlm.nih.gov/pubmed/31906837
U2 - 10.2174/1567201817666200106104332
DO - 10.2174/1567201817666200106104332
M3 - Review article
C2 - 31906837
SN - 1567-2018
VL - 17
SP - 101
EP - 111
JO - Current Drug Delivery
JF - Current Drug Delivery
IS - 2
ER -
