Novel refractive index biosensing of microcontact printed molecules on lithium niobate

Nikhil Bhalla; Shivani Sathish; Amy Q. Shen

doi:10.1109/EMBC.2016.7591141

Novel refractive index biosensing of microcontact printed molecules on lithium niobate

Nikhil Bhalla
, Shivani Sathish
, Amy Q. Shen

School of Engineering

Research output: Contribution to conference › Paper › peer-review

Abstract

This work demonstrates, for the first time, the use of lithium niobate as a biosensor that detects local refractive index changes triggered by the presence of biomolecules on its surface. The sensitivity of the sensor was found to be 242±16 nm/RIU. As a case study, we immobilized proteins (IgG antibodies) using micro-contact printing to demonstrate sensing capabilities of the device. The validated proof of concept lays a foundation for developing lithium niobate based novel optical biosensors.

Original language	English
Pages	2095-2098
DOIs	https://doi.org/10.1109/EMBC.2016.7591141
Publication status	Published (in print/issue) - 18 Oct 2016
Event	2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - Orlando, FL, USA Duration: 16 Aug 2016 → 20 Aug 2016

Conference

Conference	2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Period	16/08/16 → 20/08/16

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10.1109/EMBC.2016.7591141

http://ieeexplore.ieee.org/document/7591141/

Cite this

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title = "Novel refractive index biosensing of microcontact printed molecules on lithium niobate",

abstract = "This work demonstrates, for the first time, the use of lithium niobate as a biosensor that detects local refractive index changes triggered by the presence of biomolecules on its surface. The sensitivity of the sensor was found to be 242±16 nm/RIU. As a case study, we immobilized proteins (IgG antibodies) using micro-contact printing to demonstrate sensing capabilities of the device. The validated proof of concept lays a foundation for developing lithium niobate based novel optical biosensors.",

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AB - This work demonstrates, for the first time, the use of lithium niobate as a biosensor that detects local refractive index changes triggered by the presence of biomolecules on its surface. The sensitivity of the sensor was found to be 242±16 nm/RIU. As a case study, we immobilized proteins (IgG antibodies) using micro-contact printing to demonstrate sensing capabilities of the device. The validated proof of concept lays a foundation for developing lithium niobate based novel optical biosensors.

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Novel refractive index biosensing of microcontact printed molecules on lithium niobate

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