Novel refractive index biosensing of microcontact printed molecules on lithium niobate

Nikhil Bhalla; Shivani Sathish; Amy Q. Shen

doi:10.1109/EMBC.2016.7591141

Novel refractive index biosensing of microcontact printed molecules on lithium niobate

Nikhil Bhalla, Shivani Sathish, Amy Q. Shen

School of Engineering

Research output: Contribution to conference › Paper › peer-review

Abstract

This work demonstrates, for the first time, the use of lithium niobate as a biosensor that detects local refractive index changes triggered by the presence of biomolecules on its surface. The sensitivity of the sensor was found to be 242±16 nm/RIU. As a case study, we immobilized proteins (IgG antibodies) using micro-contact printing to demonstrate sensing capabilities of the device. The validated proof of concept lays a foundation for developing lithium niobate based novel optical biosensors.

Original language	English
Pages	2095-2098
DOIs	https://doi.org/10.1109/EMBC.2016.7591141
Publication status	Published (in print/issue) - 18 Oct 2016
Event	2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - Orlando, FL, USA Duration: 16 Aug 2016 → 20 Aug 2016

Conference

Conference	2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Period	16/08/16 → 20/08/16

Access to Document

10.1109/EMBC.2016.7591141

http://ieeexplore.ieee.org/document/7591141/

Cite this

@conference{dd35c92fa24b4623aee67a3644099f79,

title = "Novel refractive index biosensing of microcontact printed molecules on lithium niobate",

abstract = "This work demonstrates, for the first time, the use of lithium niobate as a biosensor that detects local refractive index changes triggered by the presence of biomolecules on its surface. The sensitivity of the sensor was found to be 242±16 nm/RIU. As a case study, we immobilized proteins (IgG antibodies) using micro-contact printing to demonstrate sensing capabilities of the device. The validated proof of concept lays a foundation for developing lithium niobate based novel optical biosensors.",

author = "Nikhil Bhalla and Shivani Sathish and Shen, {Amy Q.}",

year = "2016",

month = oct,

day = "18",

doi = "10.1109/EMBC.2016.7591141",

language = "English",

pages = "2095--2098",

note = "2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) ; Conference date: 16-08-2016 Through 20-08-2016",

}

TY - CONF

T1 - Novel refractive index biosensing of microcontact printed molecules on lithium niobate

AU - Bhalla, Nikhil

AU - Sathish, Shivani

AU - Shen, Amy Q.

PY - 2016/10/18

Y1 - 2016/10/18

N2 - This work demonstrates, for the first time, the use of lithium niobate as a biosensor that detects local refractive index changes triggered by the presence of biomolecules on its surface. The sensitivity of the sensor was found to be 242±16 nm/RIU. As a case study, we immobilized proteins (IgG antibodies) using micro-contact printing to demonstrate sensing capabilities of the device. The validated proof of concept lays a foundation for developing lithium niobate based novel optical biosensors.

AB - This work demonstrates, for the first time, the use of lithium niobate as a biosensor that detects local refractive index changes triggered by the presence of biomolecules on its surface. The sensitivity of the sensor was found to be 242±16 nm/RIU. As a case study, we immobilized proteins (IgG antibodies) using micro-contact printing to demonstrate sensing capabilities of the device. The validated proof of concept lays a foundation for developing lithium niobate based novel optical biosensors.

U2 - 10.1109/EMBC.2016.7591141

DO - 10.1109/EMBC.2016.7591141

M3 - Paper

SP - 2095

EP - 2098

T2 - 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Y2 - 16 August 2016 through 20 August 2016

ER -

Novel refractive index biosensing of microcontact printed molecules on lithium niobate

Abstract

Conference

Access to Document

Fingerprint

Cite this