Novel non-invasive Pressure-Volume Loop measurement for local Pulse Wave Velocity estimation

In the last four decades, hypertension doubled to 1.13 billion patients. High blood pressure (BP) is the main risk factor for cardiovascular morbidity and mortality. Arterial stiffness (AS) is a key component and poorly understood part of cardiac vital signs. Pressure-volume loop (PULoop) has been used to measure local pulse wave velocity (PWV) which is an indicator of AS [1]. We have been able to measure the PU-Loop noninvasively on palmar digital arteries. Pressure and flow waveforms are measured simultaneously at the same location. The dataset has calculated the normalized PWV of 1.48±0.4 from the slope of the line formed between two early systole points of 20-30%. PU-Loop provides an insight into contractility, preload, and hypertension and correcting factor for pulse transit time estimations.