Novel dual agonist peptide analogues derived from dogfish glucagon show promising in vitro insulin releasing actions and antihyperglycaemic activity in mice

Finbarr O'Harte; Tony NG; AM Lynch; Conlon JM; Peter Flatt

doi:10.1016/j.mce.2016.05.012

Novel dual agonist peptide analogues derived from dogfish glucagon show promising in vitro insulin releasing actions and antihyperglycaemic activity in mice

Finbarr O'Harte
, Tony NG
, AM Lynch
, Conlon JM
, Peter Flatt

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

236 Downloads (Pure)

Abstract

The antidiabetic potential of thirteen novel dogfish glucagon derived analogues were assessed in vitro and in acute in vivo studies. Stable peptide analogues enhanced insulin secretion from BRIN-BD11 β-cells (p <0.001) and reduced acute glycaemic responses following intraperitoneal glucose (25 nmol/kg) in healthy NIH Swiss mice (p <0.05-p

Original language	English
Pages (from-to)	133-144
Journal	Molecular and Cellular Endocrinology
Volume	431
Early online date	11 May 2016
DOIs	https://doi.org/10.1016/j.mce.2016.05.012
Publication status	Published (in print/issue) - 15 Aug 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Dogfish glucagon
Glucagon-like peptide-1 (GLP-1)
Glucose dependent insulinotropic polypeptide (GIP)
Glucagon
Dual agonist
Diabetes
Acute effects
Antidiabetic and antihyperglycaemic

Access to Document

10.1016/j.mce.2016.05.012

1-s2Author Accepted Manuscript, 863 KB

Cite this

@article{fac1433ca853431f8890db84ee031f0d,

title = "Novel dual agonist peptide analogues derived from dogfish glucagon show promising in vitro insulin releasing actions and antihyperglycaemic activity in mice",

abstract = "The antidiabetic potential of thirteen novel dogfish glucagon derived analogues were assessed in vitro and in acute in vivo studies. Stable peptide analogues enhanced insulin secretion from BRIN-BD11 β-cells (p <0.001) and reduced acute glycaemic responses following intraperitoneal glucose (25 nmol/kg) in healthy NIH Swiss mice (p <0.05-p",

keywords = "Dogfish glucagon, Glucagon-like peptide-1 (GLP-1), Glucose dependent insulinotropic polypeptide (GIP), Glucagon, Dual agonist, Diabetes, Acute effects, Antidiabetic and antihyperglycaemic",

author = "Finbarr O'Harte and Tony NG and AM Lynch and Conlon JM and Peter Flatt",

year = "2016",

month = aug,

day = "15",

doi = "10.1016/j.mce.2016.05.012",

language = "English",

volume = "431",

pages = "133--144",

journal = "Molecular and Cellular Endocrinology",

issn = "0303-7207",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Novel dual agonist peptide analogues derived from dogfish glucagon show promising in vitro insulin releasing actions and antihyperglycaemic activity in mice

AU - O'Harte, Finbarr

AU - NG, Tony

AU - Lynch, AM

AU - JM, Conlon

AU - Flatt, Peter

PY - 2016/8/15

Y1 - 2016/8/15

N2 - The antidiabetic potential of thirteen novel dogfish glucagon derived analogues were assessed in vitro and in acute in vivo studies. Stable peptide analogues enhanced insulin secretion from BRIN-BD11 β-cells (p <0.001) and reduced acute glycaemic responses following intraperitoneal glucose (25 nmol/kg) in healthy NIH Swiss mice (p <0.05-p

AB - The antidiabetic potential of thirteen novel dogfish glucagon derived analogues were assessed in vitro and in acute in vivo studies. Stable peptide analogues enhanced insulin secretion from BRIN-BD11 β-cells (p <0.001) and reduced acute glycaemic responses following intraperitoneal glucose (25 nmol/kg) in healthy NIH Swiss mice (p <0.05-p

KW - Dogfish glucagon

KW - Glucagon-like peptide-1 (GLP-1)

KW - Glucose dependent insulinotropic polypeptide (GIP)

KW - Glucagon

KW - Dual agonist

KW - Diabetes

KW - Acute effects

KW - Antidiabetic and antihyperglycaemic

U2 - 10.1016/j.mce.2016.05.012

DO - 10.1016/j.mce.2016.05.012

M3 - Article

SN - 0303-7207

VL - 431

SP - 133

EP - 144

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

ER -

Novel dual agonist peptide analogues derived from dogfish glucagon show promising in vitro insulin releasing actions and antihyperglycaemic activity in mice

Abstract

UN SDGs

Keywords

Access to Document

Fingerprint

Cite this