Novel dual agonist peptide analogues derived from dogfish glucagon show promising in vitro insulin releasing actions and antihyperglycaemic activity in mice

Finbarr O'Harte; Tony NG; AM Lynch; Conlon JM; Peter Flatt

doi:10.1016/j.mce.2016.05.012

Novel dual agonist peptide analogues derived from dogfish glucagon show promising in vitro insulin releasing actions and antihyperglycaemic activity in mice

Finbarr O'Harte, Tony NG, AM Lynch, Conlon JM, Peter Flatt

Research output: Contribution to journal › Article › peer-review

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Abstract

The antidiabetic potential of thirteen novel dogfish glucagon derived analogues were assessed in vitro and in acute in vivo studies. Stable peptide analogues enhanced insulin secretion from BRIN-BD11 β-cells (p <0.001) and reduced acute glycaemic responses following intraperitoneal glucose (25 nmol/kg) in healthy NIH Swiss mice (p <0.05-p

Original language	English
Pages (from-to)	133-144
Journal	Molecular and Cellular Endocrinology
Volume	431
Early online date	11 May 2016
DOIs	https://doi.org/10.1016/j.mce.2016.05.012
Publication status	Published (in print/issue) - 15 Aug 2016

Keywords

Dogfish glucagon
Glucagon-like peptide-1 (GLP-1)
Glucose dependent insulinotropic polypeptide (GIP)
Glucagon
Dual agonist
Diabetes
Acute effects
Antidiabetic and antihyperglycaemic

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mce.2016.05.012

1-s2Author Accepted Manuscript, 863 KB

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abstract = "The antidiabetic potential of thirteen novel dogfish glucagon derived analogues were assessed in vitro and in acute in vivo studies. Stable peptide analogues enhanced insulin secretion from BRIN-BD11 β-cells (p <0.001) and reduced acute glycaemic responses following intraperitoneal glucose (25 nmol/kg) in healthy NIH Swiss mice (p <0.05-p",

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AU - O'Harte, Finbarr

AU - NG, Tony

AU - Lynch, AM

AU - JM, Conlon

AU - Flatt, Peter

PY - 2016/8/15

Y1 - 2016/8/15

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KW - Dogfish glucagon

KW - Glucagon-like peptide-1 (GLP-1)

KW - Glucose dependent insulinotropic polypeptide (GIP)

KW - Glucagon

KW - Dual agonist

KW - Diabetes

KW - Acute effects

KW - Antidiabetic and antihyperglycaemic

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DO - 10.1016/j.mce.2016.05.012

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SP - 133

EP - 144

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

ER -

Novel dual agonist peptide analogues derived from dogfish glucagon show promising in vitro insulin releasing actions and antihyperglycaemic activity in mice

Abstract

Keywords

UN SDGs

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