Novel dual agonist peptide analogues derived from dogfish glucagon show promising in vitro insulin releasing actions and antihyperglycaemic activity in mice

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Abstract

The antidiabetic potential of thirteen novel dogfish glucagon derived analogues were assessed in vitro and in acute in vivo studies. Stable peptide analogues enhanced insulin secretion from BRIN-BD11 β-cells (p <0.001) and reduced acute glycaemic responses following intraperitoneal glucose (25 nmol/kg) in healthy NIH Swiss mice (p <0.05-p
LanguageEnglish
Pages133-144
JournalMolecular and Cellular Endocrinology
Volume431
Early online date11 May 2016
DOIs
Publication statusPublished - 15 Aug 2016

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Dogfish
Glucagon
Hypoglycemic Agents
Insulin
Glucose
Peptides
In Vitro Techniques

Keywords

  • Dogfish glucagon
  • Glucagon-like peptide-1 (GLP-1)
  • Glucose dependent insulinotropic polypeptide (GIP)
  • Glucagon
  • Dual agonist
  • Diabetes
  • Acute effects
  • Antidiabetic and antihyperglycaemic

Cite this

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abstract = "The antidiabetic potential of thirteen novel dogfish glucagon derived analogues were assessed in vitro and in acute in vivo studies. Stable peptide analogues enhanced insulin secretion from BRIN-BD11 β-cells (p <0.001) and reduced acute glycaemic responses following intraperitoneal glucose (25 nmol/kg) in healthy NIH Swiss mice (p <0.05-p",
keywords = "Dogfish glucagon, Glucagon-like peptide-1 (GLP-1), Glucose dependent insulinotropic polypeptide (GIP), Glucagon, Dual agonist, Diabetes, Acute effects, Antidiabetic and antihyperglycaemic",
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AU - Lynch, AM

AU - JM, Conlon

AU - Flatt, Peter

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KW - Diabetes

KW - Acute effects

KW - Antidiabetic and antihyperglycaemic

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