Novel dual agonist peptide analogues derived from dogfish glucagon show promising in vitro insulin releasing actions and antihyperglycaemic activity in mice

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Abstract

The antidiabetic potential of thirteen novel dogfish glucagon derived analogues were assessed in vitro and in acute in vivo studies. Stable peptide analogues enhanced insulin secretion from BRIN-BD11 β-cells (p <0.001) and reduced acute glycaemic responses following intraperitoneal glucose (25 nmol/kg) in healthy NIH Swiss mice (p <0.05-p
Original languageEnglish
Pages (from-to)133-144
JournalMolecular and Cellular Endocrinology
Volume431
Early online date11 May 2016
DOIs
Publication statusPublished - 15 Aug 2016

Keywords

  • Dogfish glucagon
  • Glucagon-like peptide-1 (GLP-1)
  • Glucose dependent insulinotropic polypeptide (GIP)
  • Glucagon
  • Dual agonist
  • Diabetes
  • Acute effects
  • Antidiabetic and antihyperglycaemic

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