Novel core-shell fiber delivery system for synergistic treatment of cervical cancer

Shuang Fei Shen, Li Fang Zhu, Jun Liu, Amna Ali, Aliyah Zaman, Zeeshan Ahmad, Xing Chen, Ming Wei Chang

    Research output: Contribution to journalArticle

    Abstract

    Ganoderma lucidum triterpenoids (GLT) possess advantageous characteristics including anti-inflammatory, anti-oxidant and anti-cancer properties. In this study, a drug loaded core-shell fibrous system was engineered using the coaxial electrospinning method. The core comprised polycaprolactone and GTL whilst the shell contained polyethylene oxide with anti-cancer drug methotrexate. The morphology and structure, chemical composition, biocompatibility and in vitro release profile of the encapsulated GLT was assessed. Scanning electron microscopy images showed cylindrical fibers were developed whilst fluorescence microscopy confirmed the successful formation of core-shell fibers. Increasing GLT concentration from 2 wt% to 6 wt% resulted in an increase in mean fiber diameter from 2.29 ± 1.26 μm to 4.65 ± 2.30 μm, respectively. Fourier transform infrared spectroscopy, X-ray diffraction and differential scanning calorimetry analysis all confirmed that both drugs were encapsulated in amorphous form while contact angle hysteresis showed engineered fibres to possess good hydrophilicity. In vitro drug release tests indicated the release of methotrexate (R2 = 0.9941) and GLT (R2 = 0.9924) were controlled by Fick Diffusion. In vitro cell culture experiments proved that the combined use of traditional Chinese medicine and current western medicine has good application prospects in the treatment of cervical cancer.

    Original languageEnglish
    Article number101865
    JournalJournal of Drug Delivery Science and Technology
    Volume59
    Early online date9 Jul 2020
    DOIs
    Publication statusPublished - 31 Oct 2020

    Keywords

    • Coaxial electrospinning
    • Core-shell fibers
    • Ganoderma lucidum triterpenoids
    • Methotrexate

    Fingerprint Dive into the research topics of 'Novel core-shell fiber delivery system for synergistic treatment of cervical cancer'. Together they form a unique fingerprint.

    Cite this