Novel bioglasses for bone tissue repair and regeneration: Effect of glass design on sintering ability, ion release and biocompatibility

E. Mancuso, O.A. Bretcanu, M. Marshall, M.A. Birch, A.W. McCaskie, K.W. Dalgarno

Research output: Contribution to journalArticle

9 Citations (Scopus)
1 Downloads (Pure)

Abstract

Eight novel silicate, phosphate and borate glass compositions (coded as NCLx, where x = 1 to 8), containing different oxides (i.e. MgO, MnO2, Al2O3, CaF2, Fe2O3, ZnO, CuO, Cr2O3) were designed and evaluated alongside apatite-wollastonite (used as comparison material), as potential biomaterials for bone tissue repair and regeneration. Glass frits of all the formulations were processed to have particle sizes under 53 μm, with their morphology and dimensions subsequently investigated by scanning electron microscopy (SEM). In order to establish the nature of the raw glass powders, X-ray diffraction (XRD) analysis was also performed. The sintering ability of the novel materials was determined by using hot stage microscopy (HSM). Ionic release potential was assessed by inductively coupled plasma optical emission spectroscopy (ICP-OES). Finally, the cytotoxic effect of the novel glass powders was evaluated for different glass concentrations via a colorimetric assay, on which basis three formulations are considered promising biomaterials.
Original languageEnglish
Pages (from-to)239-248
Number of pages10
JournalMaterials and Design
Volume129
Early online date12 May 2017
DOIs
Publication statusPublished - 5 Sep 2017

Keywords

  • Glass design
  • Sintering ability
  • Ion release
  • Biocompatibility
  • Bone substitutes

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